Yuling Yan1, Xian Xing1, Qiang Lu2, Xiaoze Wang1, Xuefeng Luo3, Li Yang4. 1. Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 2. Department of Ultrasonography, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 3. Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: luo_xuefeng@yeah.net. 4. Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: yangli_hx@scu.edu.cn.
Abstract
BACKGROUND: Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique used to stage liver fibrosis by measuring liver stiffness (LS). The diagnostic performance of 2D-SWE for assessing liver fibrosis in patients with primary biliary cholangitis (PBC) has not been reported before. AIMS: To investigate the diagnostic performance of 2D-SWE for staging liver fibrosis in patients with PBC by using histologic analysis as a reference standard. METHODS: Patients with PBC who underwent liver biopsy and 2D-SWE were retrospectively collected. Liver fibrosis was staged according to the Scheuer scoring system. Areas under receiver operating characteristic curve (AUROC) was constructed to assess the accuracy of 2D-SWE and serum fibrosis models for staging liver fibrosis. RESULTS: The diagnostic performance characteristics were determined for 157 patients with PBC. The AUROCs of LS measured by 2D-SWE for significant fibrosis, severe fibrosis, and cirrhosis were 0.88, 0.97 and 0.99, respectively. The cutoff values of LS measured by 2D-SWE in discriminating significant fibrosis, severe fibrosis, and cirrhosis were 10.7 kPa, 12.2 kPa and 14.1 kPa, respectively. The diagnostic accuracy of 2D-SWE for staging liver fibrosis was 73.9%. CONCLUSIONS: 2D-SWE is an efficient noninvasive method for the assessment of liver fibrosis in patients with PBC.
BACKGROUND: Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique used to stage liver fibrosis by measuring liver stiffness (LS). The diagnostic performance of 2D-SWE for assessing liver fibrosis in patients with primary biliary cholangitis (PBC) has not been reported before. AIMS: To investigate the diagnostic performance of 2D-SWE for staging liver fibrosis in patients with PBC by using histologic analysis as a reference standard. METHODS:Patients with PBC who underwent liver biopsy and 2D-SWE were retrospectively collected. Liver fibrosis was staged according to the Scheuer scoring system. Areas under receiver operating characteristic curve (AUROC) was constructed to assess the accuracy of 2D-SWE and serum fibrosis models for staging liver fibrosis. RESULTS: The diagnostic performance characteristics were determined for 157 patients with PBC. The AUROCs of LS measured by 2D-SWE for significant fibrosis, severe fibrosis, and cirrhosis were 0.88, 0.97 and 0.99, respectively. The cutoff values of LS measured by 2D-SWE in discriminating significant fibrosis, severe fibrosis, and cirrhosis were 10.7 kPa, 12.2 kPa and 14.1 kPa, respectively. The diagnostic accuracy of 2D-SWE for staging liver fibrosis was 73.9%. CONCLUSIONS: 2D-SWE is an efficient noninvasive method for the assessment of liver fibrosis in patients with PBC.