Yi-Yu Yin 1 , Nan Zhao 1 , Bin Yang 1 , Hua Xin 2 Show Affiliations »
Abstract
BACKGROUND: Sternal tumors are difficult to diagnose, and usually need to be differentiated from other diseases such as tuberculosis, osteosarcoma, intrathoracic thyroid and thymoma. The sternum is a rare site of Hodgkin's lymphoma, which is often misdiagnosed as tuberculosis on routine histopathology. CASE SUMMARY: We reported a 47-year-old female patient with chest pain in the upper sternum for 1 mo. Chest computed tomography found a mass in the upper sternum. Pathology and immunohistochemistry of the biopsy confirmed the diagnosis of typical Hodgkin's lymphoma (mixed cellularity subtype). Patient was diagnosed with primary sternal Hodgkin's lymphoma and administered 6 cycles of adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy. Patient had no tumor recurrence and progression at a follow-up visit 2 years later. CONCLUSION: This study highlights the rarity of primary sternal Hodgkin's lymphoma and the challenges of its diagnosis. A PubMed and Web of Science search revealed 10 reported cases of sternal involvement in Hodgkin's lymphoma. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
BACKGROUND: Sternal tumors are difficult to diagnose, and usually need to be differentiated from other diseases such as tuberculosis , osteosarcoma , intrathoracic thyroid and thymoma . The sternum is a rare site of Hodgkin's lymphoma , which is often misdiagnosed as tuberculosis on routine histopathology. CASE SUMMARY: We reported a 47-year-old female patient with chest pain in the upper sternum for 1 mo. Chest computed tomography found a mass in the upper sternum. Pathology and immunohistochemistry of the biopsy confirmed the diagnosis of typical Hodgkin's lymphoma (mixed cellularity subtype). Patient was diagnosed with primary sternal Hodgkin's lymphoma and administered 6 cycles of adriamycin , bleomycin , vinblastine , and dacarbazine chemotherapy. Patient had no tumor recurrence and progression at a follow-up visit 2 years later. CONCLUSION: This study highlights the rarity of primary sternal Hodgkin's lymphoma and the challenges of its diagnosis. A PubMed and Web of Science search revealed 10 reported cases of sternal involvement in Hodgkin's lymphoma . ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Entities: Chemical
Disease
Species
Keywords:
Case report; Chest pain; Hodgkin’s Lymphoma; Skeleton; Sternum
Year: 2020
PMID： 32110677 PMCID： PMC7031822 DOI： 10.12998/wjcc.v8.i3.638
Source DB: PubMed Journal: World J Clin Cases ISSN： 2307-8960 Impact factor: 1.337