Deoxyfluorination using CuF2 enabled by a Lewis base activating group strategy.

Deoxyfluorination is a primary method for the formation of C-F bonds. Bespoke reagents are commonly used due to issues associated with the low reactivity of metal fluorides. Here, we report the development of a simple strategy for deoxyfluorination using first-row transition metal fluorides that overcomes these limitations. Using CuF 2 as an exemplar, activation of an O -alkylisourea adduct formed in situ allows effective nucleophilic fluoride transfer to a range of primary and secondary alcohols. Spectroscopic investigations have been used to probe the origin of the enhanced reactivity of CuF 2 . The utility of the process towards enabling 18 F-radiolabeling is also presented.