| Literature DB >> 32108212 |
Ying Han1, Yifan Da1, Mingjia Yu2, Yaping Cheng1, Xin Wang1, Jiale Xiong1, Guoying Guo1, Yan Li3, Xianxing Jiang1, Xiaoqing Cai1.
Abstract
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the engagement of the clathrin-mediated endocytosis. The synergistic effects of NPGY motif and nona-arginine peptide were found to induce robust internalization and lysosomal trafficking, which in turn improved anti-tumor activity of an antibody-drug conjugate.Entities:
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Year: 2020 PMID： 32108212 DOI： 10.1039/d0ob00265h
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876