Jen-Sheng Pei1, Wen-Shin Chang2, Pei-Chen Hsu1, Chao-Chun Chen1, Yu-Ting Chin2, Tai-Lin Huang2, Yuan-Nian Hsu3, Chien-Chung Kuo4, Yun-Chi Wang2, Chia-Wen Tsai5, Chi-Li Gong5,6, DA-Tian Bau5,7,8. 1. Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C. 2. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. 3. Department of Family Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C. 4. Department of Pediatric Orthopedics, China Medical University Hospital, Taichung, Taiwan, R.O.C. 5. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 6. Department of Physiology, China Medical University, Taichung, Taiwan, R.O.C. 7. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. 8. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several solid cancers. The study aimed at examining the association of the it with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. MATERIALS AND METHODS: We recruited 266 patients with childhood ALL and 266 healthy controls, and rs2910164 genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The allele G was associated with decreased childhood ALL risk (OR=0.66, 95%CI=0.52-0.85, p=0.0011). Consistently, the GG genotype was associated with a decreased susceptibility (OR=0.40, 95%CI=0.23-0.67, p=0.0004). Patients with CG and GG genotypes were of earlier onset than those with CC genotype (p=0.0255 and p=0.0001). CONCLUSION: MiR146a rs2910164 G allele serves as a protective marker for childhood ALL in Taiwan. Copyright
BACKGROUND/AIM: Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146ars2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several solid cancers. The study aimed at examining the association of the it with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. MATERIALS AND METHODS: We recruited 266 patients with childhood ALL and 266 healthy controls, and rs2910164 genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The allele G was associated with decreased childhood ALL risk (OR=0.66, 95%CI=0.52-0.85, p=0.0011). Consistently, the GG genotype was associated with a decreased susceptibility (OR=0.40, 95%CI=0.23-0.67, p=0.0004). Patients with CG and GG genotypes were of earlier onset than those with CC genotype (p=0.0255 and p=0.0001). CONCLUSION:MiR146ars2910164 G allele serves as a protective marker for childhood ALL in Taiwan. Copyright
Authors: Tatiane Piedade de Souza; Darlen Cardoso de Carvalho; Alayde Viera Wanderley; Sweny Marinho Fernandes; Juliana Carla Gomes Rodrigues; Amanda Cohen-Paes; Marianne Rodrigues Fernandes; Fernando Augusto Rodrigues Mello Junior; Lucas Favacho Pastana; Lui Wallacy Morikawa Souza Vinagre; Artur Luiz da Costa Silva; Paulo Pimentel de Assumpção; Sidney Santos; André Salim Khayat; Ney Pereira Carneiro Dos Santos Journal: Am J Transl Res Date: 2020-12-15 Impact factor: 4.060
Authors: Silvia Jiménez-Morales; Juan Carlos Núñez-Enríquez; Jazmín Cruz-Islas; Vilma Carolina Bekker-Méndez; Elva Jiménez-Hernández; Aurora Medina-Sanson; Irma Olarte-Carrillo; Adolfo Martínez-Tovar; Janet Flores-Lujano; Julian Ramírez-Bello; María Luisa Pérez-Saldívar; Jorge Alfonso Martín-Trejo; Héctor Pérez-Lorenzana; Raquel Amador-Sánchez; Felix Gustavo Mora-Ríos; José Gabriel Peñaloza-González; David Aldebarán Duarte-Rodríguez; José Refugio Torres-Nava; Juan Eduardo Flores-Bautista; Rosa Martha Espinosa-Elizondo; Pedro Francisco Román-Zepeda; Luz Victoria Flores-Villegas; Edna Liliana Tamez-Gómez; Víctor Hugo López-García; José Ramón Lara-Ramos; Juana Esther González-Ulivarri; Sofía Irene Martínez-Silva; Gilberto Espinoza-Anrubio; Carolina Almeida-Hernández; Rosario Ramírez-Colorado; Luis Hernández-Mora; Luis Ramiro García-López; Gabriela Adriana Cruz-Ojeda; Arturo Emilio Godoy-Esquivel; Iris Contreras-Hernández; Abraham Medina-Hernández; María Guadalupe López-Caballero; Norma Angélica Hernández-Pineda; Jorge Granados-Kraulles; María Adriana Rodríguez-Vázquez; Delfino Torres-Valle; Carlos Cortés-Reyes; Francisco Medrano-López; Jessica Arleet Pérez-Gómez; Annel Martínez-Ríos; Antonio Aguilar-De-Los-Santos; Berenice Serafin-Díaz; María de Lourdes Gutiérrez-Rivera; Laura Elizabeth Merino-Pasaye; Gilberto Vargas-Alarcón; Minerva Mata-Rocha; Omar Alejandro Sepúlveda-Robles; Haydeé Rosas-Vargas; Alfredo Hidalgo-Miranda; Juan Manuel Mejía-Aranguré Journal: Front Oncol Date: 2021-11-05 Impact factor: 6.244