A Sharew1, J Bodilsen2, B R Hansen3, H Nielsen2,4, C T Brandt5,6. 1. Department of pulmonary and Infectious Diseases, Nordsjællands Hospital, University of Copenhagen, Dyrehavevej 29, 3400, Hilleroed, Denmark. 2. Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark. 3. Department of Infectious Diseases, University Hospital Copenhagen Hvidovre, Hvidovre, Denmark. 4. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. 5. Department of pulmonary and Infectious Diseases, Nordsjællands Hospital, University of Copenhagen, Dyrehavevej 29, 3400, Hilleroed, Denmark. Christian.thomas.brandt.01@regionh.dk. 6. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Christian.thomas.brandt.01@regionh.dk.
Abstract
BACKGROUND: Death from bacterial meningitis is rarely attributed to the actual event causing death. The present study therefore categorized and characterized the cause and time of death due to bacterial meningitis. METHODS: In a cohort of patients > 15 years of age with community acquired bacterial meningitis the medical records were reviewed, and a clinical cause of death categorized into six main categories: 1) CNS complications, 2) Systemic complications, 3) Combination of systemic and CNS complications, 4) Sudden death, 5) Withdrawal of care, or 6) Unknown. RESULTS: We identified 358 patients of which 84 (23%) died in-hospital. Causes of death were ascribed to CNS complications in 43%, Systemic complications in 39%, Combined CNS and systemic complications in 4%, Sudden death in 7% and withdrawal of care in 5%. Brain herniation, circulatory failure, intractable seizures and other brain injury were the most common specific causes of death within 14 days from admission (55%). CONCLUSION: Fatal complications due to the primary infection - meningitis - is most common within 14 days of admission. The diversity of complications causing death in meningitis suggest that determining the clinical cause of death is essential to the evaluation of novel treatment strategies.
BACKGROUND:Death from bacterial meningitis is rarely attributed to the actual event causing death. The present study therefore categorized and characterized the cause and time of death due to bacterial meningitis. METHODS: In a cohort of patients > 15 years of age with community acquired bacterial meningitis the medical records were reviewed, and a clinical cause of death categorized into six main categories: 1) CNS complications, 2) Systemic complications, 3) Combination of systemic and CNS complications, 4) Sudden death, 5) Withdrawal of care, or 6) Unknown. RESULTS: We identified 358 patients of which 84 (23%) died in-hospital. Causes of death were ascribed to CNS complications in 43%, Systemic complications in 39%, Combined CNS and systemic complications in 4%, Sudden death in 7% and withdrawal of care in 5%. Brain herniation, circulatory failure, intractable seizures and other brain injury were the most common specific causes of death within 14 days from admission (55%). CONCLUSION: Fatal complications due to the primary infection - meningitis - is most common within 14 days of admission. The diversity of complications causing death in meningitis suggest that determining the clinical cause of death is essential to the evaluation of novel treatment strategies.
Entities:
Keywords:
Bacterial meningitis; Brain herniation; Cause of death; Central nervous system complications; Sepsis; Systemic complications
Authors: Damon P Eisen; Elizabeth Hamilton; Jacob Bodilsen; Rasmus Køster-Rasmussen; Alexander J Stockdale; James Miner; Henrik Nielsen; Olga Dzupova; Varun Sethi; Rachel K Copson; Miriam Harings; Oyelola A Adegboye Journal: Sci Rep Date: 2022-01-13 Impact factor: 4.379
Authors: Bassma H Elwakil; Basant A Bakr; Mohammed M Aljeldah; Nourhan S Shehata; Yahya H Shahin; Zakia A Olama; Maria Augustyniak; Mourad A M Aboul-Soud; Abeer El Wakil Journal: Pathogens Date: 2022-08-18