Literature DB >> 32105330

Impact of Exogenous Testosterone on Reproduction in Transgender Men.

Molly B Moravek1,2, Hadrian M Kinnear3,4, Jenny George1, Jourdin Batchelor5, Ariella Shikanov1,3,6, Vasantha Padmanabhan1,7, John F Randolph1.   

Abstract

Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovarian and uterine consequences of testosterone exposure in transgender men; draw parallels with existing animal models of androgen exposure; summarize the existing literature on parenting experiences and desires in transgender people; discuss considerations for assisted reproductive technologies and fertility preservation; and identify gaps in the literature and opportunities for further research. Published by Oxford University Press on behalf of the Endocrine Society 2020.

Entities:  

Keywords:  fertility; gender-affirming hormone therapy; reproduction; transgender men

Mesh：

Substances：

Year:  2020        PMID： 32105330      PMCID： PMC7046016          DOI： 10.1210/endocr/bqaa014

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  87 in total

Review 1.  Androgens and ovarian function: translation from basic discovery research to clinical impact.

Authors:  K A Walters; V Rodriguez Paris; A Aflatounian; D J Handelsman
Journal:  J Endocrinol       Date:  2019-08       Impact factor: 4.286

2.  Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline.

Authors:  Wylie C Hembree; Peggy T Cohen-Kettenis; Louis Gooren; Sabine E Hannema; Walter J Meyer; M Hassan Murad; Stephen M Rosenthal; Joshua D Safer; Vin Tangpricha; Guy G T'Sjoen
Journal:  J Clin Endocrinol Metab       Date:  2017-11-01       Impact factor: 5.958

Review 3.  Animal models of polycystic ovary syndrome: a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk.

Authors:  Danni Shi; Donna F Vine
Journal:  Fertil Steril       Date:  2012-05-17       Impact factor: 7.329

4.  Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice.

Authors:  Li-Feng Sun; Ya-Li Yang; Tian-Xia Xiao; Meng-Xia Li; Jian V Zhang
Journal:  Reprod Fertil Dev       Date:  2019-09       Impact factor: 2.311

5.  A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones.

Authors:  Henk Asscheman; Erik J Giltay; Jos A J Megens; W Pim de Ronde; Michael A A van Trotsenburg; Louis J G Gooren
Journal:  Eur J Endocrinol       Date:  2011-01-25       Impact factor: 6.664

6.  Transgender men who experienced pregnancy after female-to-male gender transitioning.

Authors:  Alexis D Light; Juno Obedin-Maliver; Jae M Sevelius; Jennifer L Kerns
Journal:  Obstet Gynecol       Date:  2014-12       Impact factor: 7.661

7.  Association between polycystic ovary syndrome and female-to-male transsexuality.

Authors:  Tsuyoshi Baba; Toshiaki Endo; Hiroyuki Honnma; Yoshimitsu Kitajima; Takuhiro Hayashi; Hiroshi Ikeda; Naoya Masumori; Hirofumi Kamiya; Osamu Moriwaka; Tsuyoshi Saito
Journal:  Hum Reprod       Date:  2006-12-13       Impact factor: 6.918

8.  Desire to Have Children Among Transgender People in Germany: A Cross-Sectional Multi-Center Study.

Authors:  Matthias K Auer; Johannes Fuss; Timo O Nieder; Peer Briken; Sarah V Biedermann; Günter K Stalla; Matthias W Beckmann; Thomas Hildebrandt
Journal:  J Sex Med       Date:  2018-05       Impact factor: 3.802

Review 9.  Update on oogenesis in vitro.

Authors:  Raffaella Fabbri; Chiara Zamboni; Rossella Vicenti; Maria Macciocca; Roberto Paradisi; Renato Seracchioli
Journal:  Minerva Ginecol       Date:  2018-07-10

10.  Hormone therapy in transgender adults is safe with provider supervision; A review of hormone therapy sequelae for transgender individuals.

Authors:  Jamie D Weinand; Joshua D Safer
Journal:  J Clin Transl Endocrinol       Date:  2015-06
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  7 in total

1.  Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.

Authors:  E Coleman; A E Radix; W P Bouman; G R Brown; A L C de Vries; M B Deutsch; R Ettner; L Fraser; M Goodman; J Green; A B Hancock; T W Johnson; D H Karasic; G A Knudson; S F Leibowitz; H F L Meyer-Bahlburg; S J Monstrey; J Motmans; L Nahata; T O Nieder; S L Reisner; C Richards; L S Schechter; V Tangpricha; A C Tishelman; M A A Van Trotsenburg; S Winter; K Ducheny; N J Adams; T M Adrián; L R Allen; D Azul; H Bagga; K Başar; D S Bathory; J J Belinky; D R Berg; J U Berli; R O Bluebond-Langner; M-B Bouman; M L Bowers; P J Brassard; J Byrne; L Capitán; C J Cargill; J M Carswell; S C Chang; G Chelvakumar; T Corneil; K B Dalke; G De Cuypere; E de Vries; M Den Heijer; A H Devor; C Dhejne; A D'Marco; E K Edmiston; L Edwards-Leeper; R Ehrbar; D Ehrensaft; J Eisfeld; E Elaut; L Erickson-Schroth; J L Feldman; A D Fisher; M M Garcia; L Gijs; S E Green; B P Hall; T L D Hardy; M S Irwig; L A Jacobs; A C Janssen; K Johnson; D T Klink; B P C Kreukels; L E Kuper; E J Kvach; M A Malouf; R Massey; T Mazur; C McLachlan; S D Morrison; S W Mosser; P M Neira; U Nygren; J M Oates; J Obedin-Maliver; G Pagkalos; J Patton; N Phanuphak; K Rachlin; T Reed; G N Rider; J Ristori; S Robbins-Cherry; S A Roberts; K A Rodriguez-Wallberg; S M Rosenthal; K Sabir; J D Safer; A I Scheim; L J Seal; T J Sehoole; K Spencer; C St Amand; T D Steensma; J F Strang; G B Taylor; K Tilleman; G G T'Sjoen; L N Vala; N M Van Mello; J F Veale; J A Vencill; B Vincent; L M Wesp; M A West; J Arcelus
Journal:  Int J Transgend Health       Date:  2022-09-06

Review 2.  Reproductive health risks and clinician practices with gender diverse adolescents and young adults.

Authors:  Gwendolyn P Quinn; Amy C Tishelman; Diane Chen; Leena Nahata
Journal:  Andrology       Date:  2021-05-24       Impact factor: 3.842

3.  Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.

Authors:  Christian Secchi; Martina Belli; Tracy N H Harrison; Joseph Swift; CheMyong Ko; Antoni J Duleba; Dwayne Stupack; R Jeffrey Chang; Shunichi Shimasaki
Journal:  J Transl Med       Date:  2021-10-15       Impact factor: 5.531

4.  Fertility preservation and fertility treatment in transgender adolescents and adults in a Swedish region, 2013-2018.

Authors:  Ellenor Mattelin; Annika Strandell; Inger Bryman
Journal:  Hum Reprod Open       Date:  2022-02-21

Review 5.  An Individualized Approach to Managing Testosterone Therapy in the Primary Care Setting.

Authors:  Adrian Sandra Dobs; Kevin James Campbell
Journal:  Int J Gen Med       Date:  2022-10-07

6.  Fertility preservation in transgender men and the need for uniform, comprehensive counseling.

Authors:  Selena U Park; Devika Sachdev; Shelley Dolitsky; Matthew Bridgeman; Mark V Sauer; Gloria Bachmann; Juana Hutchinson-Colas
Journal:  F S Rep       Date:  2022-07-19

Review 7.  The Role of Androgen Supplementation in Women With Diminished Ovarian Reserve: Time to Randomize, Not Meta-Analyze.

Authors:  Ana Raquel Neves; Pedro Montoya-Botero; Nikolaos P Polyzos
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-17       Impact factor: 5.555
  7 in total

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