Literature DB >> 3210455

Emesis induced by cancer chemotherapeutic agents in the Suncus murinus: a new experimental model.

N Matsuki1, S Ueno, T Kaji, A Ishihara, C H Wang, H Saito.   

Abstract

Acute emetic responses to seven cancer chemotherapeutic agents (adriamycin, bleomycin, cisplatin, cyclophosphamide, 5-fluorouracil, methotrexate, mitomycin C) were studied in the Suncus murinus. Intravenous injection of the drugs caused vomiting with various latency. Cisplatin-induced emesis was prevented by the pretreatment with metoclopramide or chlorpromazine but not with domperidone. These results indicate that the Suncus murinus is a useful animal for testing emetic activities of cancer chemotherapeutics and antiemetic activities of prophylactic drugs.

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Year:  1988        PMID： 3210455     DOI： 10.1254/jjp.48.303

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  16 in total

1.  GDF15 Induces Anorexia through Nausea and Emesis.

Authors:  Tito Borner; Evan D Shaulson; Misgana Y Ghidewon; Amanda B Barnett; Charles C Horn; Robert P Doyle; Harvey J Grill; Matthew R Hayes; Bart C De Jonghe
Journal:  Cell Metab       Date:  2020-01-09       Impact factor: 27.287

2.  Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis.

Authors:  Julie L Eiseman; Michael Sciullo; Hong Wang; Jan H Beumer; Charles C Horn
Journal:  Lab Anim       Date:  2017-02-26       Impact factor: 2.471

Review 3.  Regulation of nausea and vomiting by cannabinoids.

Authors:  Linda A Parker; Erin M Rock; Cheryl L Limebeer
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

4.  Post-anesthesia vomiting: impact of isoflurane and morphine on ferrets and musk shrews.

Authors:  Charles C Horn; Kelly Meyers; Diana Pak; Allysa Nagy; Christian C Apfel; Brian A Williams
Journal:  Physiol Behav       Date:  2012-04-04

5.  Cisplatin-induced early and delayed emesis in the pigeon.

Authors:  S Tanihata; H Igarashi; M Suzuki; T Uchiyama
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

6.  Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews.

Authors:  Charles C Horn; Kelly Meyers; Audrey Lim; Matthew Dye; Diana Pak; Linda Rinaman; Bill J Yates
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2014-01-15       Impact factor: 3.619

7.  Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.

Authors:  Charles C Horn; Bart C De Jonghe; Kathleen Matyas; Ralph Norgren
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-08-26       Impact factor: 3.619

8.  Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus).

Authors:  Bart C De Jonghe; Charles C Horn
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-02-18       Impact factor: 3.619

9.  Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews.

Authors:  Charles C Horn; Liz Still; Christiana Fitzgerald; Mark I Friedman
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-11-05       Impact factor: 4.052

Review 10.  Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases.

Authors:  Paul L R Andrews; Charles C Horn
Journal:  Auton Neurosci       Date:  2006-03-23       Impact factor: 3.145
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