Mian-Hong Zheng1, Fahime Bigdeli2, Lan-Xing Gao1, Deng-Ze Wu1, Xiao-Wei Yan3, Mao-Lin Hu3, Ali Morsali2. 1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, People's Republic of China. 2. Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran. 3. College of Materials and Chemical Engineering, and Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization, Hezhou University, Hezhou, Guangxi 542800, People's Republic of China.
Abstract
AIM: A new Ag(I) complex (A3) was synthesized and evaluated for its anticancer activity against human cancer cell lines. MATERIALS AND METHODS: The complex A3 was characterized by 1H, 13C, and 31P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples. RESULTS: The interaction mode of the complex A3 with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations. CONCLUSION: The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.
AIM: A new Ag(I) complex (A3) was synthesized and evaluated for its anticancer activity against human cancer cell lines. MATERIALS AND METHODS: The complex A3 was characterized by 1H, 13C, and 31P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples. RESULTS: The interaction mode of the complex A3 with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations. CONCLUSION: The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.
Authors: Muhammad Adnan Iqbal; Muhammad Ihtisham Umar; Rosenani A Haque; Mohamed B Khadeer Ahamed; Mohd Zaini Bin Asmawi; Amin Malik Shah Abdul Majid Journal: J Inorg Biochem Date: 2015-02-07 Impact factor: 4.155
Authors: Muhammad Asif; Muhammad Adnan Iqbal; Mouayed A Hussein; Chern Ein Oon; Rosenani A Haque; Mohamed B Khadeer Ahamed; Aman Shah Abdul Majid; Amin Malik Shah Abdul Majid Journal: Eur J Med Chem Date: 2015-11-25 Impact factor: 6.514