Literature DB >> 32102335

Micronucleus Assay: The State of Art, and Future Directions.

Sylwester Sommer1, Iwona Buraczewska1, Marcin Kruszewski1,2.   

Abstract

During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage. In this minireview, we focus on the position of MN among the other genotoxicity tests, its usefulness in different applications and visibility by international organizations, such as International Atomic Energy Agency, Organization for Economic Co-operation and Development and International Organization for Standardization. In addition, the mechanism of micronuclei formation is discussed. Finally, foreseen directions of the MN development are pointed, such as automation, buccal cells MN and chromothripsis phenomenon.

Entities:  

Keywords:  biological dosimetry; biomonitoring; buccal cells; genotoxicity; genotoxicity tests; lymphocytes; micronucleus assay

Year:  2020        PMID： 32102335     DOI： 10.3390/ijms21041534

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  17 in total

1.  ER Stress and Micronuclei Cluster: Stress Response Contributes to Genome Chaos in Cancer.

Authors:  Eric Heng; Amanda Moy; Guo Liu; Henry H Heng; Kezhong Zhang
Journal:  Front Cell Dev Biol       Date:  2021-08-04

2.  Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances.

Authors:  Hui Kheng Lim; Christopher Owen Hughes; Michelle Jing Sin Lim; Jia'En Jasmine Li; Moumita Rakshit; Calvin Yeo; Kern Rei Chng; Angela Li; Joanne Sheot Harn Chan; Kee Woei Ng; David Ian Leavesley; Benjamin Paul Chapman Smith
Journal:  Arch Toxicol       Date:  2022-02-28       Impact factor: 6.168

3.  Fluctuation in radioresponse of HeLa cells during the cell cycle evaluated based on micronucleus frequency.

Authors:  Hiroaki Shimono; Atsushi Kaida; Hisao Homma; Hitomi Nojima; Yusuke Onozato; Hiroyuki Harada; Masahiko Miura
Journal:  Sci Rep       Date:  2020-11-30       Impact factor: 4.379

Review 4.  Short Assay Design for Micronucleus Detection in Human Lymphocytes.

Authors:  Guido Rincón; Claudia Sánchez
Journal:  Biomed Res Int       Date:  2021-09-11       Impact factor: 3.411

Review 5.  Plant Cytogenetics in the Micronuclei Investigation-The Past, Current Status, and Perspectives.

Authors:  Jolanta Kwasniewska; Adrianna Wiktoria Bara
Journal:  Int J Mol Sci       Date:  2022-01-24       Impact factor: 5.923

6.  The Cytokinesis-Block Micronucleus Assay on Human Isolated Fresh and Cryopreserved Peripheral Blood Mononuclear Cells.

Authors:  Simon Sioen; Karlien Cloet; Anne Vral; Ans Baeyens
Journal:  J Pers Med       Date:  2020-09-14

7.  Antimutagenic activity of nanoparticles of Rhaphidophora pinnata leaves in mice using micronucleus assay.

Authors:  Masfria Masfria; Marianne Marianne; Yade Metri Permata; Steven Octavio; Sri Mulyani
Journal:  J Adv Pharm Technol Res       Date:  2021-07-16

8.  Genoprotective Effect of Some Flavonoids against Genotoxic Damage Induced by X-rays In Vivo: Relationship between Structure and Activity.

Authors:  Miguel Alcaraz; Amparo Olivares; Daniel Gyingiri Achel; José Antonio García-Gamuz; Julián Castillo; Miguel Alcaraz-Saura
Journal:  Antioxidants (Basel)       Date:  2021-12-30

9.  A MATLAB-based program for three-dimensional quantitative analysis of micronuclei reveals that neuroinflammation induces micronuclei formation in the brain.

Authors:  Kaito Akiyama; Rio Tsuchiya; Sarasa Yano; Hikari Kubotani; Tomoki Chiba; Takeshi Nagata; Fuminori Tsuruta
Journal:  Sci Rep       Date:  2021-09-15       Impact factor: 4.379

Review 10.  Natural Ingredients Common in the Trás-os-Montes Region (Portugal) for Use in the Cosmetic Industry: A Review about Chemical Composition and Antigenotoxic Properties.

Authors:  Sara Gonçalves; Isabel Gaivão
Journal:  Molecules       Date:  2021-08-30       Impact factor: 4.411
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