Application of fractal dimension to the study of the surface ruggedness of granular solids and excipients.

This report describes the use of fractal analysis in the study of the surface ruggedness of pharmaceutical solids. A comparison of the fractal dimension of granules and excipients prepared by different techniques revealed a possible correlation between the physical behavior of these granules and their surface geometry. The applications of the proposed tool in the study of the surface geometry of pharmaceutical bulk solids are discussed.