Literature DB >> 3210051

Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.

P Foley1, H F Bradford, M Docherty, H Fillit, V N Luine, B McEwen, G Bucht, B Winblad, J Hardy.   

Abstract

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

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Year:  1988        PMID： 3210051     DOI： 10.1007/bf00314249

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  22 in total

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Authors:  T H Joh; R A Ross; D J Reis
Journal:  Anal Biochem       Date:  1974-11       Impact factor: 3.365

2.  Depolarizing stimuli and the release of physiologically active amino acids from suspensions of mammalian synaptosomes.

Authors:  H F Bradford; G W Bennett; A J Thomas
Journal:  J Neurochem       Date:  1973-09       Impact factor: 5.372

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4.  Evidence for specific immunolysis of nerve terminals using antisera against choline acetyltransferase, glutamate decarboxylase and tyrosine hydroxylase.

Authors:  M Docherty; H F Bradford; J Y Wu; T H Joh; D J Reis
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5.  Antibodies in cerebrospinal fluid of some Alzheimer disease patients recognize cholinergic neurons in the rat central nervous system.

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6.  Clinical subtypes of dementia of the Alzheimer type.

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8.  Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia.

Authors:  I Alafuzoff; R Adolfsson; G Bucht; B Winblad
Journal:  J Neurol Sci       Date:  1983 Aug-Sep       Impact factor: 3.181

9.  Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT).

Authors:  H M Wisniewski; P B Kozlowski
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10.  The significance of anti-neuronal antibodies in Alzheimer's disease.

Authors:  H Watts; P G Kennedy; M Thomas
Journal:  J Neuroimmunol       Date:  1981-03       Impact factor: 3.478
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Journal:  ISRN Neurol       Date:  2011-07-12

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6.  Anti-Chol-1 antigen, GQ1bα, antibodies are associated with Alzheimer's disease.

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  7 in total

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