Literature DB >> 32099272

Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite in the management of open Gustilo Anderson IIIB fractures. Prospective Review of 80 Patients from the Manchester Ortho-Plastic Unit.

Ahmed Aljawadi1, Amirul Islam1, Noman Jahangir1, Noman Niazi1, Zak Ferguson1, Benjamin Sephton1, Mohammed Elmajee2, Adam Reid3, Jason Wong3, Anand Pillai1.   

Abstract

BACKGROUND: This study aims to evaluate outcomes of using Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite in management of Open Gustilo-Anderson IIIB Fractures. METHODS AND
RESULTS: 80 patients were managed with single-stage "Fix and Flap" along with intra-operative Adjuvant Local Antibiotic Bio-Composite. Successful fracture union was achieved in 96.1% of patients, with a limb salvage rate of 96.25%. Infection rate was only 1.25%.
CONCLUSION: High union rate and very low deep infection rate can be predictably achieved in complex Open Gustilo-Anderson IIIB fractures by meticulous technique, use of local adjunctive antibiotics bio-composite and a combined ortho-plastic approach. Crown
Copyright © 2020 Published by Elsevier B.V. on behalf of Professor P K Surendran Memorial Education Foundation. All rights reserved.

Entities:  

Keywords:  Cerament G; Fix and flap; Gustilo anderson; Local antibiotics; Open fracture; Orthoplastic

Year:  2020        PMID: 32099272      PMCID: PMC7031137          DOI: 10.1016/j.jor.2020.01.012

Source DB:  PubMed          Journal:  J Orthop        ISSN: 0972-978X


  27 in total

Review 1.  Infection after fracture fixation: Current surgical and microbiological concepts.

Authors:  W J Metsemakers; R Kuehl; T F Moriarty; R G Richards; M H J Verhofstad; O Borens; S Kates; M Morgenstern
Journal:  Injury       Date:  2016-09-11       Impact factor: 2.586

2.  Single-stage orthoplastic reconstruction of Gustilo-Anderson Grade III open tibial fractures greatly reduces infection rates.

Authors:  J A Mathews; J Ward; T W Chapman; U M Khan; M B Kelly
Journal:  Injury       Date:  2015-08-22       Impact factor: 2.586

3.  Host classification predicts infection after open fracture.

Authors:  Thomas R Bowen; James C Widmaier
Journal:  Clin Orthop Relat Res       Date:  2005-04       Impact factor: 4.176

4.  Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.

Authors:  R B Gustilo; J T Anderson
Journal:  J Bone Joint Surg Am       Date:  1976-06       Impact factor: 5.284

5.  Fix and flap: the radical orthopaedic and plastic treatment of severe open fractures of the tibia.

Authors:  S Gopal; S Majumder; A G Batchelor; S L Knight; P De Boer; R M Smith
Journal:  J Bone Joint Surg Br       Date:  2000-09

6.  Use of antibiotics in open tibial fractures.

Authors:  M J Patzakis; J Wilkins; T M Moore
Journal:  Clin Orthop Relat Res       Date:  1983-09       Impact factor: 4.176

7.  Interobserver reliability in the Gustilo and Anderson classification of open fractures.

Authors:  B D Horn; M E Rettig
Journal:  J Orthop Trauma       Date:  1993       Impact factor: 2.512

Review 8.  Does timing to operative debridement affect infectious complications in open long-bone fractures? A systematic review.

Authors:  Mara L Schenker; Sarah Yannascoli; Keith D Baldwin; Jaimo Ahn; Samir Mehta
Journal:  J Bone Joint Surg Am       Date:  2012-06-20       Impact factor: 5.284

Review 9.  Antibiotics for preventing infection in open limb fractures.

Authors:  R A Gosselin; I Roberts; W J Gillespie
Journal:  Cochrane Database Syst Rev       Date:  2004

10.  Antibiotic Containing Bone Substitute in Major Hip Surgery: A Long Term Gentamicin Elution Study.

Authors:  Mindaugas Stravinskas; Malin Nilsson; Peter Horstmann; Michael Mørk Petersen; Sarunas Tarasevicius; Lars Lidgren
Journal:  J Bone Jt Infect       Date:  2018-04-12
View more
  1 in total

1.  In Vitro Evaluation of Gentamicin or Vancomycin Containing Bone Graft Substitute in the Prevention of Orthopedic Implant-Related Infections.

Authors:  Alessandro Bidossi; Marta Bottagisio; Nicola Logoluso; Elena De Vecchi
Journal:  Int J Mol Sci       Date:  2020-12-04       Impact factor: 5.923

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.