Gabriela F Buys-Gonçalves1, Francisco J B Sampaio1, Maria Eduarda M Silva2, Marco A Pereira-Sampaio3, Diogo B De Souza4. 1. Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil. 2. Department of Veterinary Medicine, Educational Foundation Serra Dos Órgãos, Teresópolis, Brazil. 3. Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Morphology, Fluminense Federal University, Niteroi, Brazil. 4. Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: desouza.db@gmail.com.
Abstract
BACKGROUND: The objective of this study is to quantitatively evaluate the protective effects of resveratrol for using during renal warm ischemia. METHODS: Rats were allocated into 4 groups: Sham, Sham Resveratrol, Ischemia, Ischemia Resveratrol. Sham Resveratrol and Ischemia Resveratrol received resveratrol before surgery. Ischemia and Ischemia Resveratrol had renal vessels clamped. Animals were euthanized four weeks after. Serum urea and creatinine were measured. Renal weight and volume, cortex-non-cortex areas ratio, cortical volume, glomerular volumetric density, volume-weighted mean glomerular volume and number of glomeruli per kidney were evaluated. RESULTS: Serum urea in Ischemia increased by 10.4% compared to Sham and no differences were observed among Ischemia Resveratrol and sham groups. The glomerular volumetric density and number of glomeruli of Ischemia were lower than Sham but Ischemia Resveratrol had no difference compared to sham groups. CONCLUSIONS: Preoperative administration of resveratrol has renoprotective effects, preventing the glomerular number reduction observed in warm ischemia.
BACKGROUND: The objective of this study is to quantitatively evaluate the protective effects of resveratrol for using during renal warm ischemia. METHODS:Rats were allocated into 4 groups: Sham, Sham Resveratrol, Ischemia, IschemiaResveratrol. Sham Resveratrol and IschemiaResveratrol received resveratrol before surgery. Ischemia and IschemiaResveratrol had renal vessels clamped. Animals were euthanized four weeks after. Serum urea and creatinine were measured. Renal weight and volume, cortex-non-cortex areas ratio, cortical volume, glomerular volumetric density, volume-weighted mean glomerular volume and number of glomeruli per kidney were evaluated. RESULTS: Serum urea in Ischemia increased by 10.4% compared to Sham and no differences were observed among IschemiaResveratrol and sham groups. The glomerular volumetric density and number of glomeruli of Ischemia were lower than Sham but IschemiaResveratrol had no difference compared to sham groups. CONCLUSIONS: Preoperative administration of resveratrol has renoprotective effects, preventing the glomerular number reduction observed in warm ischemia.
Authors: Mona M Ahmed; Mohamed M A Hussein; Taisir Saber; Yasmina M Abd-Elhakim Journal: Int J Environ Res Public Health Date: 2022-07-04 Impact factor: 4.614
Authors: Gabriela F Buys-Gonçalves; Francisco J B Sampaio; Marco A Pereira-Sampaio; Maria Eduarda M Silva; Diogo B De Souza Journal: Data Brief Date: 2020-04-15