Frédéric Dutheil1,2, Laetitia Zaragoza-Civale3, Bruno Pereira4, Martial Mermillod5,6, Julien S Baker7, Jeannot Schmidt8, Fares Moustafa9, Valentin Navel10. 1. Physiological and Psychosocial Stress, Université Clermont Auvergne, CNRS, LaPSCo, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Occupational and Preventive Medicine, WittyFit, France. 2. Faculty of Health, School of Exercise Science, Australian Catholic University, Melbourne, Victoria. 3. Occupational and Preventive Medicine, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France. 4. Biostatistics Unit, the Clinical Research and Innovation Direction, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France. 5. Université Grenoble Alpes, Université, Savoie Mont Blanc, CNRS, LPNC, Grenoble. 6. Institut Universitaire de France, Paris. 7. Department of Sport, Physical Education, and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong. 8. Physiological and Psychosocial Stress, Université Clermont Auvergne, CNRS, LaPSCo, CHU Clermont-Ferrand, Emergency Medicine, University Hospital of Clermont-Ferrand, France. 9. Emergency Medicine, Université Clermont Auvergne, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France. 10. Ophthalmology, Université Clermont Auvergne, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France.
Abstract
INTRODUCTION: Asbestos-related diseases and cancers represent a major public health concern. OBJECTIVE: To conduct a systematic review and meta-analysis to demonstrate that asbestos exposure increases the risk of prostate cancer. METHODS: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched using the keywords (prostate cancer OR prostatic neoplasm) AND (asbestos* OR crocidolite* OR chrysotile* OR amphibole* OR amosite*). To be included, articles needed to describe our primary outcome: Risk of prostate cancer after any asbestos exposure. RESULTS: We included 33 studies with 15,687 cases of prostate cancer among 723,566 individuals. Asbestos exposure increased the risk of prostate cancer (effect size = 1.10, 95% confidence interval [CI] = 1.05-1.15). When we considered mode of absorption, respiratory inhalation increased the risk of prostate cancer (1.10, 95% CI = 1.05-1.14). Both environmental and occupational exposure increased the risk of prostate cancer (1.25, 95% CI = 1.01-1.48; and 1.07, 1.04-1.10, respectively). For type of fibers, the amosite group had an increased risk of prostate cancer (1.12, 95% CI = 1.05-1.19), and there were no significant results for the chrysotile/crocidolite group. The risk was higher in Europe (1.12, 95% CI = 1.05-1.19), without significant results in other continents. DISCUSSION: Asbestos exposure seems to increase prostate cancer risk. The main mechanism of absorption was respiratory. Both environmental and occupational asbestos exposure were linked to increased risk of prostate cancer. CONCLUSION: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening.
INTRODUCTION: Asbestos-related diseases and cancers represent a major public health concern. OBJECTIVE: To conduct a systematic review and meta-analysis to demonstrate that asbestos exposure increases the risk of prostate cancer. METHODS: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched using the keywords (prostate cancer OR prostatic neoplasm) AND (asbestos* OR crocidolite* OR chrysotile* OR amphibole* OR amosite*). To be included, articles needed to describe our primary outcome: Risk of prostate cancer after any asbestos exposure. RESULTS: We included 33 studies with 15,687 cases of prostate cancer among 723,566 individuals. Asbestos exposure increased the risk of prostate cancer (effect size = 1.10, 95% confidence interval [CI] = 1.05-1.15). When we considered mode of absorption, respiratory inhalation increased the risk of prostate cancer (1.10, 95% CI = 1.05-1.14). Both environmental and occupational exposure increased the risk of prostate cancer (1.25, 95% CI = 1.01-1.48; and 1.07, 1.04-1.10, respectively). For type of fibers, the amosite group had an increased risk of prostate cancer (1.12, 95% CI = 1.05-1.19), and there were no significant results for the chrysotile/crocidolite group. The risk was higher in Europe (1.12, 95% CI = 1.05-1.19), without significant results in other continents. DISCUSSION: Asbestos exposure seems to increase prostate cancer risk. The main mechanism of absorption was respiratory. Both environmental and occupational asbestos exposure were linked to increased risk of prostate cancer. CONCLUSION: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening.
Authors: José Manuel Ordóñez-Mena; Ben Schöttker; Ute Mons; Mazda Jenab; Heinz Freisling; Bas Bueno-de-Mesquita; Mark G O'Doherty; Angela Scott; Frank Kee; Bruno H Stricker; Albert Hofman; Catherine E de Keyser; Rikje Ruiter; Stefan Söderberg; Pekka Jousilahti; Kari Kuulasmaa; Neal D Freedman; Tom Wilsgaard; Lisette Cpgm de Groot; Ellen Kampman; Niclas Håkansson; Nicola Orsini; Alicja Wolk; Lena Maria Nilsson; Anne Tjønneland; Andrzej Pająk; Sofia Malyutina; Růžena Kubínová; Abdonas Tamosiunas; Martin Bobak; Michail Katsoulis; Philippos Orfanos; Paolo Boffetta; Antonia Trichopoulou; Hermann Brenner Journal: BMC Med Date: 2016-04-05 Impact factor: 8.775
Authors: Haocheng Yu; Stephanie Tuminello; Naomi Alpert; Maaike van Gerwen; Seungyeul Yoo; David J Mulholland; Stuart A Aaronson; Michael Donovan; William K Oh; Yixuan Gong; Li Wang; Jun Zhu; Emanuela Taioli Journal: Carcinogenesis Date: 2022-06-27 Impact factor: 4.741