Y-X Ou1, R Bi. 1. Department of Pharmacy, Peking Union Medical College Hospital, Beijing, China. biran_1177@126.com.
Abstract
OBJECTIVE: Current conclusions on the potential influence of the single nucleotide polymorphism (SNP) of Matrix metalloproteinase-2 (MMP)-2-1306 C>T on Breast cancer (BCa) susceptibility remain controversial. This study aims to accurately clarify their relation. MATERIALS AND METHODS: The relevant literature on the relation between genetic variation of MMP-2 and BCa susceptibility was searched in PubMed, Web of School, VIP, and CNKI published before March 2019. The keywords used were as follows: "MMP-2, breast/mammary cancer/carcinoma/tumor" or "SNPs of MMP-2, breast/mammary cancer/carcinoma/tumor". Odds ratio (OR) and 95% CI of extracted data from eligible literature were calculated. RESULTS: A total of 7 studies involving 1823 BCa patients and 1899 healthy controls were included. All control genes were consistent with HWE (p>0.05). Different genetic models were utilized to clarify the potential influence of MMP-2-1306 C>T (rs243865) on BCa susceptibility. No significant correlation was identified between the SNP of MMP-2-1306 C>T and BCa susceptibility based on the calculated OR and 95% CI in different genotypes: CC vs. CT&TT: p=0.54, OR=0.88 (95% CI=0.58-1.33); TT vs. CC&CT: p=0.67, OR=1.07 (95% CI=0.79-1.44); CC vs. TT: p=0.73, OR=0.95 (95% CI=0.70-1.29); C Allele vs. T Allele: p=0.93, OR=1.02 (95% CI=0.70-1.47). CONCLUSIONS: The SNP of MMP-2-1306 C>T did not correlate to the susceptibility to BCa.
OBJECTIVE: Current conclusions on the potential influence of the single nucleotide polymorphism (SNP) of Matrix metalloproteinase-2 (MMP)-2-1306 C>T on Breast cancer (BCa) susceptibility remain controversial. This study aims to accurately clarify their relation. MATERIALS AND METHODS: The relevant literature on the relation between genetic variation of MMP-2 and BCa susceptibility was searched in PubMed, Web of School, VIP, and CNKI published before March 2019. The keywords used were as follows: "MMP-2, breast/mammary cancer/carcinoma/tumor" or "SNPs of MMP-2, breast/mammary cancer/carcinoma/tumor". Odds ratio (OR) and 95% CI of extracted data from eligible literature were calculated. RESULTS: A total of 7 studies involving 1823 BCapatients and 1899 healthy controls were included. All control genes were consistent with HWE (p>0.05). Different genetic models were utilized to clarify the potential influence of MMP-2-1306 C>T (rs243865) on BCa susceptibility. No significant correlation was identified between the SNP of MMP-2-1306 C>T and BCa susceptibility based on the calculated OR and 95% CI in different genotypes: CC vs. CT&TT: p=0.54, OR=0.88 (95% CI=0.58-1.33); TT vs. CC&CT: p=0.67, OR=1.07 (95% CI=0.79-1.44); CC vs. TT: p=0.73, OR=0.95 (95% CI=0.70-1.29); C Allele vs. T Allele: p=0.93, OR=1.02 (95% CI=0.70-1.47). CONCLUSIONS: The SNP of MMP-2-1306 C>T did not correlate to the susceptibility to BCa.