| Literature DB >> 32095387 |
Louis de Weerd1,2, Kristin Sjåvik3,4, Lars Kjelsberg Pedersen3, Sven Weum2,5, Rune Otto Hennig3,4.
Abstract
This article describes the triple use of autologous amnion graft as a new procedure in the treatment of myelomeningocele and in myelomeningocele with split cord malformation. The first amnion graft was used as a physical and mechanical barrier to protect the myelomeningocele (MMC) from desiccation and mechanical stress directly after birth. A second graft was used as a dura substitute to close the cerebrospinal fluid compartment. Autologous amnion seems to be the ideal dural graft for closure of an MMC and for an MMC with split cord malformation. A tension-free and watertight closure was obtained. With the epithelium side placed to the spinal cord and due to its beneficial effect on scar formation, the risk for tethering cord syndrome is reduced when using autologous amnion as a dural graft. The regenerative properties of autologous amnion may contribute to repair neural damage. Finally, a third amnion graft was placed beneath the perforator flap used to close the skin defect to provide a watertight barrier and to stimulate flap survival.Entities:
Year: 2020 PMID: 32095387 PMCID: PMC7015586 DOI: 10.1097/GOX.0000000000002539
Source DB: PubMed Journal: Plast Reconstr Surg Glob Open ISSN: 2169-7574
Fig. 1.Autologous amnion is used directly after birth to cover the MMC with an associated SCM in the period before surgery.
Fig. 2.Autologous amnion is used as a dural graft with its epithelium side placed to the spinal cord and adapted to the defect.
Fig. 3.Autologous amnion is placed beneath the medial dorsal intercostal artery perforator flap as an extra watertight barrier and to contribute to flap survival.