Clinical Features of Vitreomacular Traction Syndrome with Peripheral Vitreoretinal Adhesion.

PURPOSE: To retrospectively review and analyze the clinical and imaging data of patients with vitreomacular traction syndrome (VMTS) with strong peripheral vitreoretinal adhesion. SUBJECTS AND METHODS: This retrospective case-series study involved 4 eyes of 4 VMTS patients with vitreoretinal adhesion in both the macular region and the periphery who underwent vitreous surgery. In all 4 cases, preoperative refraction, fundoscopic findings, optical coherence tomography (OCT) findings, and intraoperative findings were evaluated.
RESULTS: The preoperative fundoscopy and OCT findings revealed fibrous membranes around the optic nerve head in 3 eyes. Thickened posterior vitreous membranes extending from the posterior pole to the periphery were observed in all eyes. Apparent VMTS or epimacular membrane was also found in the fellow eyes of 2 patients. The preoperative refractive errors ranged from +0.5 diopters (D) to +2.75 D (mean, +1.13 D). Intraoperatively, a thickened posterior vitreous membrane was found strongly adhered to the retina in the macula regions, optic nerve head, and periphery. In 2 eyes, when artificial posterior vitreous detachment (PVD) was created, an iatrogenic tear developed in the periphery.
CONCLUSION: The features of VMTS that cause strong peripheral vitreoretinal adhesion include the preoperative presence of a thickened posterior vitreous membrane over a wide area, hypermetropia, and a short axial length.

Introduction

Vitreomacular traction syndrome (VMTS) is a disorder that causes foveal depression via anterior traction of the foveal retina when posterior vitreous detachment (PVD) occurs.1–4 Optical coherence tomography (OCT) is very useful for not only diagnosing VMTS but also for determining the extent of vitreoretinal adhesion and detecting retinoschisis, retinal detachment, and cyst-like changes in the retina. In general, vitreoretinal adhesion is localized to the macular region and rarely observed in the peripheral area.

Here, we report 4 cases of VMTS with extremely strong vitreoretinal adhesion not only in the macular area but also around the optic nerve head (ONH) and in the periphery, and the clinical features of those 4 cases.

Subjects and Methods

This retrospective case study involved 4 eyes of 4 VMTS patients (3 females, 1 male; mean age: 75 years; range: 60–86 years) who presented with strong vitreoretinal adhesion in both the macular region and the peripheral area and who subsequently underwent vitreous surgery at the Department of Ophthalmology, Osaka Medical College, Takatsuki City, Osaka, Japan in 2017. In all 4 cases, the preoperative refraction, fundoscopy findings, optical coherence tomography (OCT) (SPECTRALIS; Heidelberg Engineering GmbH, Heidelberg, Germany) findings, intraoperative findings, and postoperative treatment courses were evaluated. For OCT examinations the standard scanning protocol involved two scans, i.e., the standard macula-focused OCT, and OCT of the ONH. This protocol was attempted for both eyes of each patient.

For surgical treatment, phacoemulsification and aspiration were first performed using a 3.0 mm wide, unsutured, sclero-corneal tunnel incision at 1.0 mm post-limbus

From the 11 o’clock position. Next, intraocular lens (VA-70AD; HOYA, Corporation, Tokyo, Japan) implantation was performed using a viscoelastic substances (Opelead HV0.85; Shiseido Co., Ltd., Tokyo, Japan) in all eyes. Vitreous surgery was then performed by resection of the cortex of the core vitreous body using 25-gauge system (CONSTELLATION® Vision System; Alcon Laboratories, Inc., Fort Worth, TX, USA). During vitreous surgery, we carefully observed the intravitreal anatomy and detected the vitreoretinal adhesions from posterior pole to peripheral area.

This case study was approved by the Ethics Committee of Osaka Medical College.

Results

Prior to surgery, the spherical equivalent refractive errors ranged from +0.5 diopters (D) to +2.75 D (mean, +1.13D). All patients were hypermetropic, and the axial length tended to be slightly short, ranging from 22.12 to 23.51 mm (mean, 22.6 mm). The preoperative corrected visual acuity ranged from 20/200 to 20/40. In all eyes, intraocular pressure was within the normal range. The clinical findings of the 4 cases in this study are shown in Table 1. Fundoscopy examination revealed slightly glossy and thickened posterior vitreous membrane (PVM) in the macular region, yet in 3 of the 4 treated eyes, a white thickened PVM was observed in a circular fashion around the ONH. In 1 of those 4 eyes, white punctate foci were also observed on the nasal side of the ONH and appeared to represent partially fibrotic PVM. In all eyes, a thickened PVM extended from the macular region to the peripheral area. Near the equator, no findings, such as foci of retinal lattice degeneration or traction retinal detachment, were observed. Fundoscopy examination revealed almost no deviation in the retinal arcade vessels, and mild formation of a retinal fold in the macular region. OCT examination revealed findings indicative of VMTS, as well as retinoschisis-like and cyst-like findings, in all eyes. Moreover, focal traction retinal detachment was found to have occurred in the macular area of 1 eye.

Table 1

The Clinical Features of the 4 Cases with VMTS

Case	Age	Sex	Affected Eye	Refraction	AL	Fellow Eye	Pre-Op VA	Post-Op VA	Complication
1	86 yrs	Male	Left	+0.75	22.77	Normal	20/200	20/25	Iatrogenic tear
2	80 yrs	Female	Left	+0.5	23.51	ERM	20/70	20/40	None
3	78 yrs	Female	Right	+2.75	22.12	Normal	20/40	20/25	Iatrogenic tear
4	86 yrs	Female	Right	+0.5	22.16	VMTS	20/200	20/50	None

Abbreviations: VMTS, vitreomacular traction syndrome; AL, axial length; Pre-Op VA, preoperative corrected visual acuity; Post-Op VA, postoperative corrected visual acuity; ERM, epiretinal membrane.

For surgical treatment, phacoemulsification and intraocular lens implantation were first performed in all eyes, followed by resection of the cortex of the core vitreous body. In 4 eyes, the posterior vitreous body was found to have not been detached, and the thickened PVM was found to have adhered to the entire retina. With vitreous forceps, the PVM was detached from the macular region and the ONH toward the periphery to create an artificial PVD. The sites in the macular region with strong adhesion were dissected, as needed, with vitreous scissors. Next, the artificial PVD was created toward the periphery. In 1 eye with punctate white proliferative membranes at the nasal side, the sites of strong adhesion were dissected, as needed, with vitreous scissors. After being detached from the retina, the PVM was clearly visually identified as white thickened membrane-like tissue. All 4 eyes showed strong vitreoretinal adhesion in the equatorial region. Its extent was in one temporal quadrant in 1 eye, one nasal quadrant in 1 eye, two temporal-to-inferior quadrants in 1 eye, and two nasal-to-inferior quadrants in 1 eye. For the 2 eyes with two quadrants of adhesion, an iatrogenic tear was formed in the equatorial region, and peripheral vitreous shaving was also performed to reduce residual vitreous traction. Moreover, intraocular laser photocoagulation was applied around the iatrogenic tear in those 2 eyes, followed by intraocular simultaneous fluid-air exchange. Subsequently, 0.8-mL of 100% sulfur hexafluoride (SF6) gas was injected into the vitreous cavity.

After surgery, the patients were instructed to remain in the lateral position. Moreover, the postoperative courses were found to be favorable in all cases. In all eyes, the fundoscopy and OCT findings, as well as the corrected visual acuity, were improved (Figures 1–4).

Figure 1

The clinical findings in Case 1. Prior to surgery, fundus imaging revealed no particular abnormality in the right eye (A), yet a thickened posterior vitreous membrane extended from the macular region to the peripheral area in the left eye (B). Preoperative examination by optical coherence tomography (OCT) revealed findings indicative of no particular abnormality in the right eye (C), yet vitreomacular traction syndrome (VMTS), as well as epiretinal membrane (ERM) in the left eye (D). Intraoperative findings of the left eye revealed that a thickened PVM had adhered to the entire retina. After being detached from the retina, the PVM was clearly visually identified as white thickened membrane-like tissue (E). Iatrogenic tear was formed in the inferior-nasal equatorial region (F). Post-surgery, OCT findings revealed that the left eye was ameliorated and that the corrected visual acuity had improved from 20/200 to 20/25 (G).

Figure 4

The clinical findings in Case 4. Prior to surgery, fundus imaging revealed a thickened PVM extending from the macular region to the peripheral area and an impending macular hole formation in the right eye (A), yet no particular abnormality in the left eye (B). Preoperative examination by OCT revealed findings indicative of VMTS, as well as focal traction retinal detachment, in the right eye (C), and slight VMTS in the left eye (D). Intraoperative findings of the right eye revealed that a thickened PVM had adhered to the entire retina and the ONH (E, F). Post-surgery, OCT findings revealed that the right eye was ameliorated and that the corrected visual acuity improved from 20/200 to 20/50 (G).

The clinical findings in Case 2. Prior to surgery, fundus imaging revealed a thickened PVM in the macula region and around the optic nerve head (ONH) in the right eye (A), and slight epiretinal membrane in the left eye (B). Preoperative examination by OCT revealed findings indicative of VMTS in the right eye (C), and ERM and retinoschisis in the left eye (D). Intraoperative findings of the right eye revealed that a thickened PVM had adhered to the entire retina, as well as white punctate foci on the nasal side of the ONH (E, F). Post-surgery, OCT findings revealed that the right eye was ameliorated and that the corrected visual acuity improved from 20/70 to 20/40 (G).

The clinical findings in Case 3. Prior to surgery, fundus imaging revealed a slightly thickened PVM extending from the macular region to the peripheral area in the right eye (A), yet no particular abnormality in the left eye (B). Preoperative examination by OCT revealed findings indicative of VMTS in the right eye (C), yet no particular abnormality in the left eye (D). Intraoperative findings of the right eye revealed strong vitreoretinal adhesion in the equatorial region of the site in which an artificial posterior vitreous detachment (PVD) was created (E), and that an iatrogenic tear was formed in the nasal equatorial region (F). Post-surgery, OCT findings revealed that the right eye was ameliorated and that the corrected visual acuity improved from 20/40 to 20/25 (G).

Discussion

In cases of VMTS, the vitreoretinal adhesion predominantly occurs in the macular region. However, VMTS cases with peripheral adhesion are relatively rare. VMTS with a thick veil-like vitreous membrane exhibits strong adhesion in not only the macular region but also the peripheral area in some cases, as was observed in our 4 cases. In those 4 eyes, the vitreoretinal adhesion was widely extended, like a sheet, from the macular region to the periphery, and strong adhesion was also observed around the ONH.

Although the causes of the thickened vitreous membrane remain unknown, some type of vitreoretinal dystrophy might be involved. Reportedly, vitreous dystrophy with such a thickened PVM includes familial exudative vitreoretinopathy, Stickler syndrome, and Wagner disease.5–7 In 2 of the 4 eyes in this present study, the conditions were found to be unilateral, and the other 2 eyes did not show either a dragged disc or peripheral retinal abnormalities that were suggestive of such vitreous dystrophy. Moreover, in those 4 cases, there was no presence of any syndromic features and familial histories that would point towards one of the dystrophies. Although we did not perform genetic investigations for any of the dystrophies, there is little possibility of those 4 cases being any type of inherited dystrophy.

In regard to VMTS with peripheral vitreoretinal adhesion, although there have been sporadic reports of the presence of peripheral vitreoretinal adhesion, few reports have indicated an association between VMTS and a thickened PVM, as was observed in our 4 cases. Gribomont et al examined the peripheral vitreoretinal adhesion in 63 eyes with epimacular membrane (EMM) and 25 eyes with VMTS, and reported that the incidence of an intraoperative iatrogenic tear and postoperative retinal detachment was 1.5% in the EMM group, yet 8% in the VMTS group, thus significantly higher in VMTS.8 Day et al, who reportedly injected SF6 into the vitreous cavity and performed artificial PVD using SF6 gas in 9 eyes with VMTS, found that a tear was formed in the periphery of 1 eye.9 Madi et al reported 8 cases of retinal detachment that resulted from a peripheral tear that formed after artificial PVD using ocriplasmin injection for VMTS, thus indicating that the peripheral retinal conditions need to be examined prior to surgery.10 Silva et al also reported similar cases.11 Georgalas et al reported a case of VMTS with peripheral traction retinal detachment.12 As described in those reports, VMTS appears to be more frequently associated with peripheral vitreoretinal adhesion than ordinary EMM.

On the other hand, it should be noted that there have also been reported cases of VMTS with vitreoretinal adhesion around the ONH, as was observed in our 4 cases. Hixson et al described a 62-year-old woman with VMTS in whom strong adhesion of a thickened PVM was observed not only in the macular region but also around the ONH.13 In a report by Brasseur et al, the authors indicated that because the severity and the sites of vitreoretinal adhesion greatly vary among individual patients with VMTS, attention should also be paid to adhesion in areas other than the macular region when vitreous surgery is performed.14

In cases of VMTS with such a thickened PVM, vitreous surgery should be carefully performed, while considering the possible presence of vitreoretinal adhesion around the ONH and in the periphery. For this purpose, it appears important to perform a detailed ophthalmologic examination prior to surgery, including the periphery, with fundoscopy. In a previous study by Koizumi et al, the authors performed 3-dimensional (3-D) OCT to assess vitreoretinal adhesion in 48 eyes with EMM or VMTS. They found that PVD was present in 30 of 36 eyes with EMM, yet in the other 6 eyes, PVD was absent and vitreoretinal adhesion was present in the periphery.15 Thus, 3-D OCT may hold potential as a useful future tool for preoperative assessment of the eye.

Conclusion

The findings in this study showed that the features of VMTS that cause strong peripheral vitreoretinal adhesion include the preoperative presence of a thickened PVM over a wide area, hypermetropia, and a short-axial length.