Turgay Ucak1, Erel Icel2, Hayati Yilmaz2, Yucel Karakurt2, Gamze Tasli2, Adem Ugurlu2, Erdinc Bozkurt3. 1. Department of Ophthalmology, Faculty of Medicine, Erzincan University, Erzincan, Turkey. turgayucak10@gmail.com. 2. Department of Ophthalmology, Faculty of Medicine, Erzincan University, Erzincan, Turkey. 3. Department of Ophthalmology, Faculty of Medicine, Kafkas University, Kars, Turkey.
Abstract
PURPOSE: The aim of this study was to determine the macular changes using optical coherence tomography (OCT) and OCT-angiography (OCT-A) in eyes with high myopia. Determining the alterations in vascular structures can provide a clearer understanding of the pathophysiological mechanisms of this disease and help define new treatment options and preventive measures. MATERIALS AND METHODS: Ninety-two patients with high myopia (axial length ≥ 26 mm) and 70 control cases without any known systemic or ocular diseases were enrolled in this prospective study. One eye of each patient was included in the statistical analyses. RESULTS: Retinal nerve fiber layer (RNFL) thickness and Early Treatment Diabetic Retinopathy Study (ETDRS) macula map values were lower in myopia compared with the controls. Both superior and inferior ganglion cell complex (GCC) thicknesses were significantly thinner in the high myopia compared with the controls (p < 0.001). Regarding the OCT-A findings, although superficial or deep foveal avascular zones (FAZ) did not significantly differ between the two groups, the density values of superficial and deep microvessels were significantly lower in the high myopia group compared with the control cases. CONCLUSIONS: In patients with high myopia, with an increase in the axial length and a decrease in RNFL and GCC thicknesses, the vascular densities of the superficial and deep retina were reduced in the macular region.
PURPOSE: The aim of this study was to determine the macular changes using optical coherence tomography (OCT) and OCT-angiography (OCT-A) in eyes with high myopia. Determining the alterations in vascular structures can provide a clearer understanding of the pathophysiological mechanisms of this disease and help define new treatment options and preventive measures. MATERIALS AND METHODS: Ninety-two patients with high myopia (axial length ≥ 26 mm) and 70 control cases without any known systemic or ocular diseases were enrolled in this prospective study. One eye of each patient was included in the statistical analyses. RESULTS: Retinal nerve fiber layer (RNFL) thickness and Early Treatment Diabetic Retinopathy Study (ETDRS) macula map values were lower in myopia compared with the controls. Both superior and inferior ganglion cell complex (GCC) thicknesses were significantly thinner in the high myopia compared with the controls (p < 0.001). Regarding the OCT-A findings, although superficial or deep foveal avascular zones (FAZ) did not significantly differ between the two groups, the density values of superficial and deep microvessels were significantly lower in the high myopia group compared with the control cases. CONCLUSIONS: In patients with high myopia, with an increase in the axial length and a decrease in RNFL and GCC thicknesses, the vascular densities of the superficial and deep retina were reduced in the macular region.
Authors: Peter M Maloca; Silvia Feu-Basilio; Julia Schottenhamml; Philippe Valmaggia; Hendrik P N Scholl; Josep Rosinés-Fonoll; Sara Marin-Martinez; Nadja Inglin; Michael Reich; Clemens Lange; Catherine Egan; Sandrine Zweifel; Adnan Tufail; Richard F Spaide; Javier Zarranz-Ventura Journal: Sci Rep Date: 2022-03-07 Impact factor: 4.379