Sergio Hernández-Da Mota1, Virgilio Lima-Gómez2, Ernesto Rodríguez-Ayala3, Jorge Jans Fromow-Guerra4, Enrique Alfonso Roig Melo-Granados5. 1. Clínica David, Ophthalmologic Unit, Morelia, Michoacán; Ophthalmology Department, Ciudad de México, Mexico. 2. Secretaría de Salud, Hospital Juárez de México, Ophthalmology Department, Ciudad de México, Mexico. 3. Universidad Anáhuac Norte, Estado de México Hospital "Dr. Luis Sánchez Bulnes", Mexico City, Mexico. 4. Asociación para Evitar la Ceguera en México, Hospital "Dr. Luis Sánchez Bulnes", Mexico City, Mexico. 5. Hospital Civil de Guadalajara, Jalisco. Mexico.
Abstract
INTRODUCTION: Patients with diabetic macular edema can develop fundus autofluorescence alterations; thus far, these alterations have been more widely studied with scanning or confocal laser systems. OBJECTIVE: To describe and classify fundus autofluorescence abnormal patterns in patients with diabetic macular edema using the fundus autofluorescence system with a flash camera. METHOD: Observational, retrospective, cross-sectional, descriptive study. Fundus autofluorescence digital images of non-comparative cases with untreated diabetic macular edema, obtained and stored with a flash camera system, were assessed. Inter-observer variability was evaluated. RESULTS: 37 eyes of 20 patients were included. Lens opacity was the most common cause of inadequate image quality. Five different fundus autofluorescence patterns were observed: decreased (13%), normal (40%), single-spot hyper-autofluorescent (17 %), multiple-spot hyper-autofluorescent (22 %) and plaque-like hyper-autofluorescent (8 %). The kappa coefficient was 0.906 (p = 0.000). CONCLUSIONS: Different fundus autofluorescence phenotypic patterns are observed with flash camera systems in patients with diabetic macular edema. A more accurate phenotypic classification could help establish prognostic factors for visual loss or for the design of clinical trials for diabetic macular edema. Copyright:
INTRODUCTION: Patients with diabetic macular edema can develop fundus autofluorescence alterations; thus far, these alterations have been more widely studied with scanning or confocal laser systems. OBJECTIVE: To describe and classify fundus autofluorescence abnormal patterns in patients with diabetic macular edema using the fundus autofluorescence system with a flash camera. METHOD: Observational, retrospective, cross-sectional, descriptive study. Fundus autofluorescence digital images of non-comparative cases with untreated diabetic macular edema, obtained and stored with a flash camera system, were assessed. Inter-observer variability was evaluated. RESULTS: 37 eyes of 20 patients were included. Lens opacity was the most common cause of inadequate image quality. Five different fundus autofluorescence patterns were observed: decreased (13%), normal (40%), single-spot hyper-autofluorescent (17 %), multiple-spot hyper-autofluorescent (22 %) and plaque-like hyper-autofluorescent (8 %). The kappa coefficient was 0.906 (p = 0.000). CONCLUSIONS: Different fundus autofluorescence phenotypic patterns are observed with flash camera systems in patients with diabetic macular edema. A more accurate phenotypic classification could help establish prognostic factors for visual loss or for the design of clinical trials for diabetic macular edema. Copyright:
Authors: Marion R Munk; Gabor Mark Somfai; Marc D de Smet; Guy Donati; Marcel N Menke; Justus G Garweg; Lala Ceklic Journal: Int J Mol Sci Date: 2022-07-08 Impact factor: 6.208