| Literature DB >> 32087570 |
Javad Masoumi1, Abdollah Jafarzadeh2, Hossein Khorramdelazad3, Morteza Abbasloui4, Jalal Abdolalizadeh5, Najmeh Jamali6.
Abstract
Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, prostate, thymus, testis, ovary, lungs, kidneys, stomach, and adipose tissue. The apelin/APJ axis is involved in a number of physiological and pathological processes. The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. The apelin also stops the apoptosis of cancer cells. The apelin/APJ axis was considered in this review as an attractive therapeutic target for cancer treatment.Entities:
Keywords: Apelin; Cancer; Therapeutic potentials
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Year: 2020 PMID： 32087570 DOI： 10.1016/j.advms.2020.02.002
Source DB: PubMed Journal: Adv Med Sci ISSN： 1896-1126 Impact factor: 3.287