Literature DB >> 3208746

A new type of transforming growth factor-beta, TGF-beta 3.

R Derynck1, P B Lindquist, A Lee, D Wen, J Tamm, J L Graycar, L Rhee, A J Mason, D A Miller, R J Coffey.   

Abstract

A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.

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Year:  1988        PMID： 3208746      PMCID： PMC454948          DOI： 10.1002/j.1460-2075.1988.tb03257.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  42 in total

1.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

2.  DNA sequence analysis by primed synthesis.

Authors:  A J Smith
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

3.  3' non-coding region sequences in eukaryotic messenger RNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

4.  Serum contains a platelet-derived transforming growth factor.

Authors:  C B Childs; J A Proper; R F Tucker; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

5.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

6.  A system for shotgun DNA sequencing.

Authors:  J Messing; R Crea; P H Seeburg
Journal:  Nucleic Acids Res       Date:  1981-01-24       Impact factor: 16.971

7.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

Authors:  R K Assoian; A Komoriya; C A Meyers; D M Miller; M B Sporn
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157

8.  Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

Authors:  S M Seyedin; P R Segarini; D M Rosen; A Y Thompson; H Bentz; J Graycar
Journal:  J Biol Chem       Date:  1987-02-15       Impact factor: 5.157

9.  Thyroid or glucocorticoid hormone induces pre-growth-hormone mRNA and its probable nuclear precursor in rat pituitary cells.

Authors:  P R Dobner; E S Kawasaki; L Y Yu; F C Bancroft
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

10.  Transforming growth factor production by chemically transformed cells.

Authors:  H L Moses; E L Branum; J A Proper; R A Robinson
Journal:  Cancer Res       Date:  1981-07       Impact factor: 12.701
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  79 in total

1.  Transforming growth factor-ßs as modulators of pericellular proteolytic events.

Authors:  J Keski-Oja; J Lohi; M Laiho
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

2.  Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

Authors:  A J Celeste; J A Iannazzi; R C Taylor; R M Hewick; V Rosen; E A Wang; J M Wozney
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

Review 3.  TGF-beta: problems and prospects.

Authors:  M B Sporn; A B Roberts
Journal:  Cell Regul       Date:  1990-11

4.  Epigenetic Interactions and Gene Expression in Peri-Implantation Mouse Embryo Development.

Authors:  Jean J Latimer; Roger A Pedersen
Journal:  Mod Cell Biol       Date:  1993

Review 5.  Growth inhibitors: molecular diversity and roles in cell proliferation.

Authors:  K Miyazaki; T Horio
Journal:  In Vitro Cell Dev Biol       Date:  1989-10

6.  Stimulation of rat endothelial cell transforming growth factor-beta production by bleomycin.

Authors:  S H Phan; M Gharaee-Kermani; F Wolber; U S Ryan
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808

7.  Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif.

Authors:  R Lafyatis; F Denhez; T Williams; M Sporn; A Roberts
Journal:  Nucleic Acids Res       Date:  1991-12-11       Impact factor: 16.971

8.  A GC-rich domain with bifunctional effects on mRNA and protein levels: implications for control of transforming growth factor beta 1 expression.

Authors:  L Scotto; R K Assoian
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

9.  Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

Authors:  J R Merwin; W Newman; L D Beall; A Tucker; J Madri
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

10.  Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.

Authors:  A R Lopez; J Cook; P L Deininger; R Derynck
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
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