Matjaz Jereb1, Matej Mavric2, Miha Skvarc3, Alja Drobnic4, Spela Dolenc5, Natalija Planinc Strunjas6, Boris Luksic7, Nina Grasselli Kmet8. 1. Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. matjaz.jereb@kclj.si. 2. Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. mavricm@gmail.com. 3. Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. miha.skvarc@mf.uni-lj.si. 4. Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. alja.drobnic@gmail.com. 5. Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. spela.dolenc@gmail.com. 6. Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. natalija.strunjas@gmail.com. 7. Department of Infectious Diseases, Clinical Hospital Center, Split, Croatia. boris.luksic1@st.t-com.hr. 8. Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia. dr.ninika@gmail.com.
Abstract
INTRODUCTION: Sepsis represents a major cause of morbidity and mortality in critically ill patients. Early diagnosis and appropriate treatment have a crucial influence on survival. The aim of this study was to evaluate the diagnostic and prognostic role of presepsin (sCD14) in patients with sepsis. METHODOLOGY: Fifty-four consecutive adult patients with sepsis and 26 patients with aseptic meningitis as a control group were included in this prospective observational study. In all patients included in the study, levels of C-reactive protein (CRP), presepsin, lactate, and a count of leukocytes and neutrophils were determined on admission. In those with suspected bacterial infection, two separate blood cultures were obtained and procalcitonin (PCT) concentration was detected. Plasma presepsin and PCT concentrations in septic group patients were followed on days 2, 3 and 7 after enrollment. RESULTS: The median presepsin serum concentration in patients with sepsis was 1614 pg/mL and in the control group it was 203 pg/mL (p < 0.001). Presepsin levels in patients with septic shock were higher than in sepsis patients (p < 0.014). The mean presepsin concentrations were higher in deceased than in surviving patients (p = 0.009). The trend of changes in presepsin concentrations in deceased patients was significantly different than in the surviving patients (p = 0.018). There were no statistically significant differences in the concentration of presepsin or other biomarkers in patients with Gram negative or Gram positive bacteria. CONCLUSIONS: Presepsin may be used as a diagnostic marker of systemic bacterial infection and can predict the severity and outcome of sepsis. Copyright (c) 2019 Matjaz Jereb, Matej Mavric, Miha Skvarc, Alja Drobnic, Spela Dolenc, Natalija Strunjas, Boris Luksic, Nina Kmet.
INTRODUCTION:Sepsis represents a major cause of morbidity and mortality in critically illpatients. Early diagnosis and appropriate treatment have a crucial influence on survival. The aim of this study was to evaluate the diagnostic and prognostic role of presepsin (sCD14) in patients with sepsis. METHODOLOGY: Fifty-four consecutive adult patients with sepsis and 26 patients with aseptic meningitis as a control group were included in this prospective observational study. In all patients included in the study, levels of C-reactive protein (CRP), presepsin, lactate, and a count of leukocytes and neutrophils were determined on admission. In those with suspected bacterial infection, two separate blood cultures were obtained and procalcitonin (PCT) concentration was detected. Plasma presepsin and PCT concentrations in septic group patients were followed on days 2, 3 and 7 after enrollment. RESULTS: The median presepsin serum concentration in patients with sepsis was 1614 pg/mL and in the control group it was 203 pg/mL (p < 0.001). Presepsin levels in patients with septic shock were higher than in sepsispatients (p < 0.014). The mean presepsin concentrations were higher in deceased than in surviving patients (p = 0.009). The trend of changes in presepsin concentrations in deceased patients was significantly different than in the surviving patients (p = 0.018). There were no statistically significant differences in the concentration of presepsin or other biomarkers in patients with Gram negative or Gram positive bacteria. CONCLUSIONS: Presepsin may be used as a diagnostic marker of systemic bacterial infection and can predict the severity and outcome of sepsis. Copyright (c) 2019 Matjaz Jereb, Matej Mavric, Miha Skvarc, Alja Drobnic, Spela Dolenc, Natalija Strunjas, Boris Luksic, Nina Kmet.