Sarah A Eisenstein1,2, Kevin J Black1,2,3,4, Amjad Samara1, Jonathan M Koller1, Julia P Dunn5, Tamara Hershey1,2,3, Samuel Klein5, Gordon I Smith5. 1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. 2. Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA. 3. Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA. 4. Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, USA. 5. Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract
OBJECTIVE: This study determined whether striatal dopamine (DA) release is affected by food ingestion and whether the DA response to high-calorie food images is greater in the fasted than in the fed state in people with obesity. METHODS: Striatal DA release was evaluated in 10 people with obesity and prediabetes after consuming a meal to satiation and after fasting overnight as well as in response to viewing images of high-calorie compared with low-calorie foods after consuming a meal to satiation or fasting overnight by using positron emission tomography with [11 C]raclopride injection. RESULTS: Striatal DA D2/D3 receptor availability was not different during fasted and fed conditions. Viewing images of high-calorie foods induced striatal DA release relative to viewing images of low-calorie foods (P < 0.05), but there was no difference in the magnitude of the response between fasting and fed conditions. CONCLUSIONS: People with obesity and prediabetes do not increase striatal DA release after eating a meal to satiation compared with fasting overnight and fail to inhibit DA release in response to high-calorie food stimuli after eating a meal to satiation. These data suggest that impaired DA signaling contributes to greater energy intake during meals in this population.
OBJECTIVE: This study determined whether striatal dopamine (DA) release is affected by food ingestion and whether the DA response to high-calorie food images is greater in the fasted than in the fed state in people with obesity. METHODS: Striatal DA release was evaluated in 10 people with obesity and prediabetes after consuming a meal to satiation and after fasting overnight as well as in response to viewing images of high-calorie compared with low-calorie foods after consuming a meal to satiation or fasting overnight by using positron emission tomography with [11 C]raclopride injection. RESULTS: Striatal DA D2/D3 receptor availability was not different during fasted and fed conditions. Viewing images of high-calorie foods induced striatal DA release relative to viewing images of low-calorie foods (P < 0.05), but there was no difference in the magnitude of the response between fasting and fed conditions. CONCLUSIONS:People with obesity and prediabetes do not increase striatal DA release after eating a meal to satiation compared with fasting overnight and fail to inhibit DA release in response to high-calorie food stimuli after eating a meal to satiation. These data suggest that impaired DA signaling contributes to greater energy intake during meals in this population.
Authors: Thomas Siessmeier; Yun Zhou; Hans-Georg Buchholz; Christian Landvogt; Ingo Vernaleken; Markus Piel; Ralf Schirrmacher; Frank Rösch; Mathias Schreckenberger; Dean F Wong; Paul Cumming; Gerhard Gründer; Peter Bartenstein Journal: J Nucl Med Date: 2005-06 Impact factor: 10.057
Authors: Sharmili Edwin Thanarajah; Heiko Backes; Alexandra G DiFeliceantonio; Kerstin Albus; Anna Lena Cremer; Ruth Hanssen; Rachel N Lippert; Oliver A Cornely; Dana M Small; Jens C Brüning; Marc Tittgemeyer Journal: Cell Metab Date: 2018-12-27 Impact factor: 27.287