| Literature DB >> 32086857 |
Masaaki Kurahashi1, Yoshihiko Kito2, Salah A Baker1, Libby K Jennings1, James G R Dowers1, Sang Don Koh1, Kenton M Sanders1.
Abstract
Transcriptome data revealed α1 adrenoceptors (ARs) expression in platelet-derived growth factor receptor α+ cells (PDGFRα+ cells) in murine colonic musculature. The role of PDGFRα+ cells in sympathetic neural regulation of murine colonic motility was investigated. Norepinephrine (NE), via α1A ARs, activated a small conductance Ca2+ -activated K+ (SK) conductance, evoked outward currents and hyperpolarized PDGFRα+ cells (the α1A AR-SK channel signal pathway). α1 AR agonists increased intracellular Ca2+ transients in PDGFRα+ cells and inhibited spontaneous phasic contractions (SPCs) of colonic muscle through activation of a SK conductance. Sympathetic nerve stimulation inhibited both contractions of distal colon and propulsive contractions represented by the colonic migrating motor complexes (CMMCs) via the α1A AR-SK channel signal pathway. Postsynaptic signaling through α1A ARs in PDGFRα+ cells is a novel mechanism that conveys part of stress responses in the colon. PDGFRα+ cells appear to be a primary effector of sympathetic neural regulation of murine colonic motility.Entities:
Keywords: PDGFRα+ cells; colonic motility; sympathetic neural regulation; α1 adrenoceptor
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Year: 2020 PMID： 32086857 PMCID： PMC7147814 DOI： 10.1096/fj.201903134R
Source DB: PubMed Journal: FASEB J ISSN： 0892-6638 Impact factor: 5.191