Tatsuya Tada1, Hiroki Uchida1, Tomomi Hishinuma1, Shin Watanabe2, Mari Tohya1, Kyoko Kuwahara-Arai1, San Mya3, Khin Nyein Zan3, Teruo Kirikae4, Htay Htay Tin3. 1. Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. 2. Department of Microbiome Research, Juntendo University Graduate School of Medicine, Tokyo, Japan. 3. National Health Laboratory, Yangon, Myanmar. 4. Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: t-kirikae@juntendo.ac.jp.
Abstract
OBJECTIVE: The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar. METHODS: A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified. RESULTS: Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored blaNDM-1, and 28 did armA or armA2 CONCLUSIONS: A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.
OBJECTIVE: The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar. METHODS: A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified. RESULTS: Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored blaNDM-1, and 28 did armA or armA2 CONCLUSIONS:A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.
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