Literature DB >> 32084556

The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.

Jonathon Keck1, James P Chambers1, Aravind Kancharla1, Dona Haj Bashir1, Laura Henley1, Katherine Schenkel1, Kevin Castillo1, M Neal Guentzel1, Rishein Gupta2, Bernard P Arulanandam3.   

Abstract

Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.
Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Bacterial burdens; Chlamydia sp; Gene regulation; IFN-γ; Lung; miR-155; microRNA

Mesh：

Substances：

Year:  2020        PMID： 32084556      PMCID： PMC7434643          DOI： 10.1016/j.micinf.2020.02.005

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  37 in total

1.  Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae.

Authors:  Catarina V Nogueira; Xuqing Zhang; Nicholas Giovannone; Erica L Sennott; Michael N Starnbach
Journal:  J Immunol       Date:  2015-01-30       Impact factor: 5.422

2.  CD4⁺CD25⁺Foxp3⁺ regulatory T cells promote Th17 responses and genital tract inflammation upon intracellular Chlamydia muridarum infection.

Authors:  Jessica M Moore-Connors; Robert Fraser; Scott A Halperin; Jun Wang
Journal:  J Immunol       Date:  2013-08-16       Impact factor: 5.422

3.  The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection.

Authors:  Heather K Maxion; Wei Liu; Mi-Hyang Chang; Kathleen A Kelly
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

4.  Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88.

Authors:  Uma M Nagarajan; David M Ojcius; Lynn Stahl; Roger G Rank; Toni Darville
Journal:  J Immunol       Date:  2005-07-01       Impact factor: 5.422

5.  Analyses of polymorphisms in the inflammasome-associated NLRP3 and miRNA-146A genes in the susceptibility to and tubal pathology of Chlamydia trachomatis infection.

Authors:  W Wang; F R Stassen; H-M Surcel; H Ohman; A Tiitinen; J Paavonen; H J C de Vries; R Heijmans; J Pleijster; S A Morré; S Ouburg
Journal:  Drugs Today (Barc)       Date:  2009-11       Impact factor: 2.245

6.  Identification of a microRNA signature in dendritic cell vaccines for cancer immunotherapy.

Authors:  Kim Holmstrøm; Ayako Wakatsuki Pedersen; Mogens Helweg Claesson; Mai-Britt Zocca; Simon Skjøde Jensen
Journal:  Hum Immunol       Date:  2010-01       Impact factor: 2.850

7.  SOCS-1 protects against Chlamydia pneumoniae-induced lethal inflammation but hampers effective bacterial clearance.

Authors:  Tangbin Yang; Patrik Stark; Katrin Janik; Hans Wigzell; Martin E Rottenberg
Journal:  J Immunol       Date:  2008-03-15       Impact factor: 5.422

8.  A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner.

Authors:  Li-Fan Lu; Georg Gasteiger; I-Shing Yu; Ashutosh Chaudhry; Jing-Ping Hsin; Yuheng Lu; Paula D Bos; Ling-Li Lin; Carolyn L Zawislak; Sunglim Cho; Joseph C Sun; Christina S Leslie; Shu-Wha Lin; Alexander Y Rudensky
Journal:  Immunity       Date:  2015-07-07       Impact factor: 31.745

9.  MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro.

Authors:  Camilla Cerutti; Patricia Soblechero-Martin; Dongsheng Wu; Miguel Alejandro Lopez-Ramirez; Helga de Vries; Basil Sharrack; David Kingsley Male; Ignacio Andres Romero
Journal:  Fluids Barriers CNS       Date:  2016-05-31

10.  MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.

Authors:  Richard Y Kim; Jay C Horvat; James W Pinkerton; Malcolm R Starkey; Ama T Essilfie; Jemma R Mayall; Prema M Nair; Nicole G Hansbro; Bernadette Jones; Tatt Jhong Haw; Krishna P Sunkara; Thi Hiep Nguyen; Andrew G Jarnicki; Simon Keely; Joerg Mattes; Ian M Adcock; Paul S Foster; Philip M Hansbro
Journal:  J Allergy Clin Immunol       Date:  2016-06-10       Impact factor: 10.793
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  2 in total

1.  Influence of Fetuin-A on Chlamydia muridarum Pulmonary Infection.

Authors:  Faria Mahjabeen; Jieh-Juen Yu; James P Chambers; Rishein Gupta; Bernard P Arulanandam
Journal:  Int J Microbiol       Date:  2022-04-19

2.  Natural Killer Cells Regulate Pulmonary Macrophages Polarization in Host Defense Against Chlamydial Respiratory Infection.

Authors:  Lei Zhao; Jing Li; Xiaoqing Zhou; Qianqian Pan; Weiming Zhao; Xi Yang; Hong Wang
Journal:  Front Cell Infect Microbiol       Date:  2022-01-04       Impact factor: 5.293
  2 in total

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