Joshua P Metlay1, Grant W Waterer2. 1. Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 2. Royal Perth Hospital and University of Western Australia, Perth, Australia.
Abstract
PURPOSE OF REVIEW: The American Thoracic Society and Infectious Diseases Society of America recently released their joint guideline for the diagnosis and treatment of adults with community-acquired pneumonia (CAP). The co-chairs of the guideline committee provide a summary of the guideline process, key recommendations from the new guideline and future directions for CAP research. RECENT FINDINGS: The guideline committee included 14 experts from the two societies. Sixteen questions for the guideline were selected using the PICO format. The GRADE approach was utilized to review the available evidence and generate recommendations. The recommendations included expanded microbiological testing for patients suspected of drug-resistant infections, empiric first-line therapy recommendations for outpatients and inpatients including use of beta-lactam monotherapy for uncomplicated outpatients, elimination of healthcare-associated pneumonia as a treatment category, and not recommending corticosteroids as routine adjunct therapy. SUMMARY: CAP is a major cause of morbidity and mortality. Effective antibiotic therapy is available and remains largely empirical. New diagnostic tests and treatment options are emerging and will lead to guideline updates in the future.
PURPOSE OF REVIEW: The American Thoracic Society and Infectious Diseases Society of America recently released their joint guideline for the diagnosis and treatment of adults with community-acquired pneumonia (CAP). The co-chairs of the guideline committee provide a summary of the guideline process, key recommendations from the new guideline and future directions for CAP research. RECENT FINDINGS: The guideline committee included 14 experts from the two societies. Sixteen questions for the guideline were selected using the PICO format. The GRADE approach was utilized to review the available evidence and generate recommendations. The recommendations included expanded microbiological testing for patients suspected of drug-resistant infections, empiric first-line therapy recommendations for outpatients and inpatients including use of beta-lactam monotherapy for uncomplicated outpatients, elimination of healthcare-associated pneumonia as a treatment category, and not recommending corticosteroids as routine adjunct therapy. SUMMARY: CAP is a major cause of morbidity and mortality. Effective antibiotic therapy is available and remains largely empirical. New diagnostic tests and treatment options are emerging and will lead to guideline updates in the future.
Authors: Nehal Farouk; Walaa Mohamed Omar Ashry; Hanan A El-Hagrasy; Eman F Mohamed; Heba H Eltrawy; Asmaa M El-Nasser; Walaa Shipl; Shahinaz El Attar; Lobna Kh Sakr; Maisa A Abdel Wahab; Eman M Abdelsalam; Fawzia A Sharaf; Inass Hassan Ahmad Journal: Int J Gen Med Date: 2022-06-10
Authors: Luis Felipe Reyes; Esteban Garcia-Gallo; Jennifer Pinedo; Manuela Saenz-Valcarcel; Leo Celi; Alejandro Rodriguez; Grant Waterer Journal: Clin Infect Dis Date: 2021-05-04 Impact factor: 9.079