OBJECTIVE: Poststroke depression (PSD) has a heterogeneous presentation and is often accompanied by cognitive impairment. This study aimed to identify distinct dimensions of depressive symptoms in older adults with PSD and to evaluate their relationship to cognitive functioning. DESIGN: Cross-sectional factor and correlational analyses of patients with poststroke depression. SETTING: Patients were recruited from the community and from acute inpatient stroke rehabilitation hospitals. PARTICIPANTS: Participants had suffered a stroke and met DSM-IV criteria for major depression (≥18 Montgomery Åsberg Depression Scale; MADRS). INTERVENTION: None. MEASUREMENTS: MADRS was used to quantify depression severity at study entry. Neuropsychological assessment at the time of study entry consisted of measures of Global Cognition, Attention, Executive Function, Processing Speed, Immediate Memory, Delayed Memory, and Language. RESULTS: There were 135 (age ≥50) older adult participants with PSD and varying degrees of cognitive impairment (MMSE Total ≥20). Factor analysis of the MADRS identified three factors, that is sadness, distress, and apathy. Items comprising each factor were totaled and correlated with neuropsychological domain z-score averages. Symptoms of the apathy factor (lassitude, inability to feel) were significantly associated with greater impairment in executive function, memory, and global cognition. Symptoms of the sadness and distress factors had no relationship to cognitive impairment. CONCLUSION: PSD consists of three correlated dimensions of depressive symptoms. Apathy symptoms are associated with cognitive impairment across several neuropsychological domains. PSD patients with prominent apathy may benefit from careful attention to cognitive functions and by interventions that address both psychopathology and behavioral deficits resulting from cognitive impairment.
OBJECTIVE:Poststroke depression (PSD) has a heterogeneous presentation and is often accompanied by cognitive impairment. This study aimed to identify distinct dimensions of depressive symptoms in older adults with PSD and to evaluate their relationship to cognitive functioning. DESIGN: Cross-sectional factor and correlational analyses of patients with poststroke depression. SETTING:Patients were recruited from the community and from acute inpatient stroke rehabilitation hospitals. PARTICIPANTS: Participants had suffered a stroke and met DSM-IV criteria for major depression (≥18 Montgomery Åsberg Depression Scale; MADRS). INTERVENTION: None. MEASUREMENTS: MADRS was used to quantify depression severity at study entry. Neuropsychological assessment at the time of study entry consisted of measures of Global Cognition, Attention, Executive Function, Processing Speed, Immediate Memory, Delayed Memory, and Language. RESULTS: There were 135 (age ≥50) older adult participants with PSD and varying degrees of cognitive impairment (MMSE Total ≥20). Factor analysis of the MADRS identified three factors, that is sadness, distress, and apathy. Items comprising each factor were totaled and correlated with neuropsychological domain z-score averages. Symptoms of the apathy factor (lassitude, inability to feel) were significantly associated with greater impairment in executive function, memory, and global cognition. Symptoms of the sadness and distress factors had no relationship to cognitive impairment. CONCLUSION:PSD consists of three correlated dimensions of depressive symptoms. Apathy symptoms are associated with cognitive impairment across several neuropsychological domains. PSDpatients with prominent apathy may benefit from careful attention to cognitive functions and by interventions that address both psychopathology and behavioral deficits resulting from cognitive impairment.
Authors: George S Alexopoulos; Patrick J Raue; Faith Gunning; Dimitris N Kiosses; Dora Kanellopoulos; Cristina Pollari; Samprit Banerjee; Patricia A Arean Journal: Am J Geriatr Psychiatry Date: 2015-12-17 Impact factor: 4.105
Authors: Yvette I Sheline; Carl F Pieper; Deanna M Barch; Kathleen Welsh-Bohmer; Kathleen Welsh-Boehmer; Robert C McKinstry; James R MacFall; Gina D'Angelo; Keith S Garcia; Kenneth Gersing; Consuelo Wilkins; Warren Taylor; David C Steffens; Ranga R Krishnan; P Murali Doraiswamy Journal: Arch Gen Psychiatry Date: 2010-03
Authors: Genevieve S Yuen; Saumya Bhutani; Bryony J Lucas; Faith M Gunning; Bassem AbdelMalak; Joanna K Seirup; Sibel A Klimstra; George S Alexopoulos Journal: Am J Geriatr Psychiatry Date: 2014-06-26 Impact factor: 4.105
Authors: S Stephens; R A Kenny; E Rowan; L Allan; R N Kalaria; M Bradbury; C G Ballard Journal: Int J Geriatr Psychiatry Date: 2004-11 Impact factor: 3.485
Authors: Genevieve S Yuen; Faith M Gunning; Eric Woods; Sibel A Klimstra; Matthew J Hoptman; George S Alexopoulos Journal: J Affect Disord Date: 2014-05-22 Impact factor: 4.839