Literature DB >> 320807

Anti-asthmatic properties of a new peroral drug (HC 20-5II).

J P Girard, M Cuevas.   

Abstract

A clinical trial was performed with a new substance (HC 20-511) derived from the cycloheptothiophene group used in the management of asthma. Twenty-four asthma patients were treated at random, with HC 20-511 or placebo or the antihistaminic substance, clemastin (Tavegyl). A statistical evaluation of the results unequivocally demonstrates good protection with a single dose of 2.0 mg or two times 1.0 mg for 3 days against a challenging antigen, compared with the placebo or the antihistaminic agent. Tolerance was excellent.

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Year:  1977        PMID: 320807     DOI: 10.1111/j.1398-9995.1977.tb02701.x

Source DB:  PubMed          Journal:  Acta Allergol        ISSN: 0001-5148


  4 in total

1.  Inhibition of histamine release from human lung in vitro by antihistamines and related drugs.

Authors:  M K Church; C F Gradidge
Journal:  Br J Pharmacol       Date:  1980-08       Impact factor: 8.739

2.  Ketotifen and asthma.

Authors:  J K Sarsfield
Journal:  Arch Dis Child       Date:  1981-04       Impact factor: 3.791

3.  Effect of antihistamines and antiallergic drugs on responses to allergen and histamine provocation tests in asthma.

Authors:  M J Phillips; S Ollier; C Gould; R J Davies
Journal:  Thorax       Date:  1984-05       Impact factor: 9.139

4.  Effect of oral sodium cromoglycate and ketotifen in fish-induced bronchial asthma.

Authors:  R Ellul-Micallef
Journal:  Thorax       Date:  1983-07       Impact factor: 9.139

  4 in total

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