Nikou Pishevar1, Omid Fathi2,3, Carl H Backes1,2,3, Edward G Shepherd2,3, Leif D Nelin4,5,6. 1. Center for Perinatal Research, Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. 2. Small Baby ICU, Nationwide Children's Hospital, Columbus, OH, USA. 3. Department of Pediatrics, The Ohio State University, Columbus, OH, USA. 4. Center for Perinatal Research, Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. leif.nelin@nationwidechildrens.org. 5. Small Baby ICU, Nationwide Children's Hospital, Columbus, OH, USA. leif.nelin@nationwidechildrens.org. 6. Department of Pediatrics, The Ohio State University, Columbus, OH, USA. leif.nelin@nationwidechildrens.org.
Abstract
BACKGROUND: There are no available predictive models for survival in extremely preterm (EP) infants admitted to a referral Level IV neonatal intensive care unit (NICU) after the first day of life (DOL). OBJECTIVE: To determine if there are clinical variables present at admission that are associated with survival in an outborn EP population. STUDY DESIGN: Data were analyzed from EP infants admitted before DOL 100 from 2008 to 2016 (n = 744). RESULTS: We found that prophylactic indomethacin (OR 1.98 (1.20-3.25) p = 0.007), admit DOL (OR 1.05 (1.02-1.08) p < 0.001), and birth in Franklin County, (OR 2.02 (95% CI, 1.04-3.90) p = 0.04) were all associated with survival. Using ROC analysis, the area under the curve for the provisional survival score was 0.69 (95% CI, 0.64-0.75; p < 0.0001). CONCLUSIONS: There are factors on admission to a referral Level IV NICU associated with survival in EP patients.
BACKGROUND: There are no available predictive models for survival in extremely preterm (EP) infants admitted to a referral Level IV neonatal intensive care unit (NICU) after the first day of life (DOL). OBJECTIVE: To determine if there are clinical variables present at admission that are associated with survival in an outborn EP population. STUDY DESIGN: Data were analyzed from EP infants admitted before DOL 100 from 2008 to 2016 (n = 744). RESULTS: We found that prophylactic indomethacin (OR 1.98 (1.20-3.25) p = 0.007), admit DOL (OR 1.05 (1.02-1.08) p < 0.001), and birth in Franklin County, (OR 2.02 (95% CI, 1.04-3.90) p = 0.04) were all associated with survival. Using ROC analysis, the area under the curve for the provisional survival score was 0.69 (95% CI, 0.64-0.75; p < 0.0001). CONCLUSIONS: There are factors on admission to a referral Level IV NICU associated with survival in EP patients.
Authors: Hibo H Abdi; Carl H Backes; Molly K Ball; Maria M Talavera-Barber; Mark A Klebanoff; Sudarshan R Jadcherla; Tahagod H Mohamed; Jonathan L Slaughter Journal: J Perinatol Date: 2021-03-04 Impact factor: 2.521