Literature DB >> 3207988

Selective blockade by nifedipine of 'purinergic' rather than adrenergic nerve-mediated vasopressor responses in the pithed rat.

J M Bulloch1, J C McGrath.   

Abstract

1. Nifedipine can attenuate pressor responses to sympathetic nerve stimulation both in the presence and in the absence of alpha-adrenoceptor blocking agents. 2. In the presence of alpha,beta-methylene ATP, nifedipine produces only a small attenuation of the vasopressor response. 3. Nifedipine attenuates the vasopressor response produced by intravenous bolus administration of alpha,beta-methylene ATP. 4. The results suggest that the purinergic component of the vasopressor response to stimulation of the sympathetic outflow in the rat is subject to blockade by nifedipine, whereas the alpha-adrenoceptor-mediated response to co-transmitter noradrenaline is relatively resistant.

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Year:  1988        PMID： 3207988      PMCID： PMC1854210          DOI： 10.1111/j.1476-5381.1988.tb11695.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  21 in total

1.  Evidence for ATP and noradrenaline as cotransmitters in sympathetic nerves.

Authors:  G Burnstock; P Sneddon
Journal:  Clin Sci (Lond)       Date:  1985       Impact factor: 6.124

2.  Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens.

Authors:  A G Blakeley; D A Brown; T C Cunnane; A M French; J C McGrath; N C Scott
Journal:  Nature       Date:  1981-12-24       Impact factor: 49.962

3.  Separation of adrenergic and non-adrenergic contractions to field stimulation in the rat vas deferens.

Authors:  D A Brown; J R Docherty; A M French; A MacDonald; J C McGrath; N C Scott
Journal:  Br J Pharmacol       Date:  1983-06       Impact factor: 8.739

4.  The effect of cations on the electrical properties of the smooth muscle cells of the guinea-pig vas deferens.

Authors:  M R Bennett
Journal:  J Physiol       Date:  1967-06       Impact factor: 5.182

5.  The effect of pithing and of nerve stimulation on the depletion of noradrenaline by reserpine in the rat anococcygeus muscle and vas deferens.

Authors:  J S Gillespie; J C McGrath
Journal:  Br J Pharmacol       Date:  1974-12       Impact factor: 8.739

6.  Inhibition of excitatory junction potentials in guinea-pig vas deferens by alpha, beta-methylene-ATP: further evidence for ATP and noradrenaline as cotransmitters.

Authors:  P Sneddon; G Burnstock
Journal:  Eur J Pharmacol       Date:  1984-04-13       Impact factor: 4.432

7.  The effect of sodium and calcium on the action potential of the smooth muscle of the guinea-pig taenia coli.

Authors:  A Brading; E Bülbring; T Tomita
Journal:  J Physiol       Date:  1969-02       Impact factor: 5.182

8.  A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.

Authors:  J S Gillespie; A Maclaren; D Pollock
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739

9.  Analysis of the alpha-adrenoceptor-mediated, and other, components in the sympathetic vasopressor responses of the pithed rat.

Authors:  N A Flavahan; T L Grant; J Greig; J C McGrath
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

10.  AN ELECTROPHYSIOLOGICAL INVESTIGATION OF THE ACTIONS OF SOME AUTONOMIC BLOCKING DRUGS ON TRANSMISSION IN THE GUINEA-PIG VAS DEFERENS.

Authors:  G BURNSTOCK; M E HOLMAN
Journal:  Br J Pharmacol Chemother       Date:  1964-12
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  7 in total

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Authors:  J M Bulloch; K Starke
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

2.  Different sensitivities of rabbit isolated blood vessels exhibiting co-transmission to the slow calcium channel blocker, nifedipine.

Authors:  J M Bulloch; A MacDonald; J C McGrath
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

3.  Olcegepant blocks neurogenic and non-neurogenic CGRPergic vasodepressor responses and facilitates noradrenergic vasopressor responses in pithed rats.

Authors:  V H Avilés-Rosas; E Rivera-Mancilla; B A Marichal-Cancino; G Manrique-Maldonado; A H Altamirano-Espinoza; A Maassen Van Den Brink; C M Villalón
Journal:  Br J Pharmacol       Date:  2017-05-02       Impact factor: 8.739

4.  Properties of P2X and P2Y receptors are dependent on artery diameter in the rat mesenteric bed.

Authors:  D P Gitterman; R J Evans
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

5.  Antagonism by nifedipine of contraction and Ca2(+)-influx evoked by ATP in guinea-pig urinary bladder.

Authors:  T Katsuragi; S Usune; T Furukawa
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

6.  Predominant role of the dopamine D3 receptor subtype for mediating the quinpirole-induced inhibition of the vasopressor sympathetic outflow in pithed rats.

Authors:  Inna Ruiz-Salinas; Abimael González-Hernández; Guadalupe Manrique-Maldonado; Bruno A Marichal-Cancino; Alain H Altamirano-Espinoza; Carlos M Villalón
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-02-19       Impact factor: 3.000

7.  Modulatory effects of endothelin-1 on purinergic and adrenergic components of sympathetically-mediated contractile activity of rabbit saphenous artery.

Authors:  V N Mutafova-Yambolieva; R G Radomirov
Journal:  Br J Pharmacol       Date:  1994-08       Impact factor: 8.739
  7 in total

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