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Literature DB >> 3207984

Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum.

Abstract

1. The affinity of the antagonist dicyclomine for subtypes of muscarinic receptors has been assessed in the myenteric plexus-longitudinal muscle preparation of the guinea-pig. 2. Dicyclomine had a high affinity (pA2 9.13) for the neuronal M1-receptor whose activation by pilocarpine causes an increase in acetylcholine release. Dicyclomine had a low affinity for both the prejunctional M2-receptor (pA2 7.61) mediating inhibition of the electrically-evoked acetylcholine release and the postjunctional M2-receptor (pA2 7.21). 3. It is concluded that dicyclomine distinguishes between M1- and M2-muscarinic receptors in functional experiments.

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Year: 1988 PMID： 3207984 PMCID： PMC1854096 DOI： 10.1111/j.1476-5381.1988.tb11647.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

10 in total

1. THE DUAL MODE OF THE ANTISPASMODIC EFFECT OF DICYCLOMINE HYDROCHLORIDE.

Authors: W R MCGRATH; R E LEWIS; W L KUHN
Journal: J Pharmacol Exp Ther Date: 1964-12 Impact factor: 4.030

2. Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors.

Authors: H N Doods; M J Mathy; D Davidesko; K J van Charldorp; A de Jonge; P A van Zwieten
Journal: J Pharmacol Exp Ther Date: 1987-07 Impact factor: 4.030

Review 3. Muscarinic receptor subtypes: a critique of the current classification and a proposal for a working nomenclature.

Authors: R M Eglen; R L Whiting
Journal: J Auton Pharmacol Date: 1986-12

4. Antimuscarinic and noncompetitive antagonist properties of dicyclomine hydrochloride in isolated human and rabbit bladder muscle.

Authors: J W Downie; D A Twiddy; S A Awad
Journal: J Pharmacol Exp Ther Date: 1977-06 Impact factor: 4.030

5. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

6. Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus.

Authors: H Kilbinger; M Nafziger
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-01 Impact factor: 3.000

7. Comparison of affinities of muscarinic antagonists to pre- and postjunctional receptors in the guinea-pig ileum.

Authors: H Kilbinger; S Halim; G Lambrecht; W Weiler; I Wessler
Journal: Eur J Pharmacol Date: 1984-08-17 Impact factor: 4.432

8. Dicyclomine, benzhexol and oxybutynine distinguish between subclasses of muscarinic binding sites.

Authors: L Nilvebrant; B Sparf
Journal: Eur J Pharmacol Date: 1986-04-09 Impact factor: 4.432

9. Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine.

Authors: A Giachetti; E Giraldo; H Ladinsky; E Montagna
Journal: Br J Pharmacol Date: 1986-09 Impact factor: 8.739

10. Muscarinic M1 and M2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system.

Authors: R A North; B E Slack; A Surprenant
Journal: J Physiol Date: 1985-11 Impact factor: 5.182

10 in total

4 in total

1. Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.

Authors: G W Sawyer; G Lambrecht; F J Ehlert
Journal: Br J Pharmacol Date: 2000-04 Impact factor: 8.739