Mingquan Guo1,2,3, Jianfeng Yao4, Feng Yang1, Wenjian Liu1, Huijing Bai5, Jianxia Ma4, Xingchen Ma1, Jinghao Zhang1, Yi Fang1, Yingxin Miao1, Jianqin Sun5, Yanmei Zhang1,2,3, Hu Zhao1,2,3. 1. Department of Laboratory Medicine, Huadong Hospital affiliated to Fudan University, Shanghai 200040, PR China. 2. Shanghai Key Laboratory of Clinical Geriatric Medicine affiliated to Shanghai 200040, PR China. 3. Research Center on Aging & Medicine affiliated to Fudan University, Shanghai 200040, PR China. 4. Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai 200040, PR China. 5. Clinical Nutrition Center, Huadong Hospital affiliated to Fudan University, Shanghai 200040, PR China.
Abstract
Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were significantly different from healthy controls. Additionally, the species diversity of healthy controls was greater than that of FC patients. Indeed, the abundance of Firmicutes and Proteobacteria was significantly decreased, whereas that of Bacteroides, Prevotella, Lactococcus, Ruminococcus and Butyricimonas was remarkably increased in FC patients. Conclusion: Elderly FC patients appear to have a unique intestinal microbiota profile. Our findings should provide insight regarding the pathogenic mechanism of FC and evidence for exploring new therapeutic strategies in elderly FC patients.
Aim: To identify intestinal microbiota compositions in elderly functional constipation (FC) patients. Materials & methods: Fecal samples from 61 FC patients and 48 healthy age-matched volunteers were analyzed through 16S rRNA gene sequencing. Results: The intestinal microbiota compositions of FC patients were significantly different from healthy controls. Additionally, the species diversity of healthy controls was greater than that of FC patients. Indeed, the abundance of Firmicutes and Proteobacteria was significantly decreased, whereas that of Bacteroides, Prevotella, Lactococcus, Ruminococcus and Butyricimonas was remarkably increased in FC patients. Conclusion: Elderly FC patients appear to have a unique intestinal microbiota profile. Our findings should provide insight regarding the pathogenic mechanism of FC and evidence for exploring new therapeutic strategies in elderly FC patients.