OBJECTIVE: We aimed to determine the association between striatal dopaminergic depletion, cerebral β-amyloid deposition, and cognitive dysfunction in Lewy body disease (LBD). METHODS: This cross-sectional study recruited 48 LBD patients (30 with dementia and 18 with mild cognitive impairment) and 15 control subjects from a university-based hospital. We measured the striatal dopamine transporter (DAT) activity and regional β-amyloid burden using18 F-FP-CIT positron emission tomography (PET) and 18 F-florbetaben (FBB) PET, respectively. The relationship between striatal FP-CIT uptake, regional cortical FBB uptake, and cognitive function scores was evaluated using path analyses. We also investigated the effects of striatal FP-CIT uptake and cortical FBB uptake on the interval between motor symptom and dementia onset. RESULTS: Reduced striatal FP-CIT uptake was associated with increased FBB uptake in the posterior cortical regions, most prominently in the occipital cortices. Reduced FP-CIT uptake in the anterior putamen was associated with visuospatial dysfunction with mediation of increased occipital FBB uptake. Reduced FP-CIT uptake in the posterior putamen and an increased parietal FBB uptake were independently associated with memory dysfunction. Reduced striatal FP-CIT uptake was associated with attention, language, and frontal/executive dysfunction, independent of amyloid deposition. Increased FBB uptake, especially in the parietal cortex, was associated with earlier onset of dementia. INTERPRETATION: Our results suggest that occipital β-amyloid deposition may contribute to the association between striatal dopaminergic depletion and visuospatial dysfunction in LBD patients. Although the effects of reduced DAT activity are more prominent than those of β-amyloid burden on cognitive dysfunction, the latter affects the onset of cognitive dysfunction. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
OBJECTIVE: We aimed to determine the association between striatal dopaminergic depletion, cerebral β-amyloid deposition, and cognitive dysfunction in Lewy body disease (LBD). METHODS: This cross-sectional study recruited 48 LBDpatients (30 with dementia and 18 with mild cognitive impairment) and 15 control subjects from a university-based hospital. We measured the striatal dopamine transporter (DAT) activity and regional β-amyloid burden using18 F-FP-CIT positron emission tomography (PET) and 18 F-florbetaben (FBB) PET, respectively. The relationship between striatal FP-CIT uptake, regional cortical FBB uptake, and cognitive function scores was evaluated using path analyses. We also investigated the effects of striatal FP-CIT uptake and cortical FBB uptake on the interval between motor symptom and dementia onset. RESULTS: Reduced striatal FP-CIT uptake was associated with increased FBB uptake in the posterior cortical regions, most prominently in the occipital cortices. Reduced FP-CIT uptake in the anterior putamen was associated with visuospatial dysfunction with mediation of increased occipital FBB uptake. Reduced FP-CIT uptake in the posterior putamen and an increased parietal FBB uptake were independently associated with memory dysfunction. Reduced striatal FP-CIT uptake was associated with attention, language, and frontal/executive dysfunction, independent of amyloid deposition. Increased FBB uptake, especially in the parietal cortex, was associated with earlier onset of dementia. INTERPRETATION: Our results suggest that occipital β-amyloid deposition may contribute to the association between striatal dopaminergic depletion and visuospatial dysfunction in LBDpatients. Although the effects of reduced DAT activity are more prominent than those of β-amyloid burden on cognitive dysfunction, the latter affects the onset of cognitive dysfunction. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Authors: Han Soo Yoo; Seun Jeon; Enrica Cavedo; MinJin Ko; Mijin Yun; Phil Hyu Lee; Young H Sohn; Michel J Grothe; Stefan Teipel; Harald Hampel; Alan C Evans; Byoung Seok Ye Journal: Neurology Date: 2021-12-30 Impact factor: 9.910
Authors: Young-Gun Lee; Seong Ho Jeong; Mincheol Park; Sung Woo Kang; Kyoungwon Baik; Seun Jeon; Phil Hyu Lee; Young Ho Sohn; Byoung Seok Ye Journal: NPJ Parkinsons Dis Date: 2022-05-11
Authors: Young-Gun Lee; Seun Jeon; Sung Woo Kang; Mincheol Park; Kyoungwon Baik; Han Soo Yoo; Seok Jong Chung; Seong Ho Jeong; Jin Ho Jung; Phil Hyu Lee; Young Ho Sohn; Alan C Evans; Byoung Seok Ye Journal: Alzheimers Dement (Amst) Date: 2021-05-21