Ethan G Lester1,2, Eric A Macklin2,3, Scott Plotkin2,4, Ana-Maria Vranceanu5,6. 1. Integrated Brain Health Clinical and Research Program, Psychiatry Department, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA. 2. Harvard Medical School, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA. 3. Biostatistics Center, Massachusetts General Hospital, 50 Staniford Street, St 560, Boston, MA, 02114, USA. 4. Neurofibromatosis Clinic, Massachusetts General Hospital, 32 Fruit Street, Yawkey Building 9E, Boston, MA, 02114, USA. 5. Integrated Brain Health Clinical and Research Program, Psychiatry Department, Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA. avranceanu@mgh.harvard.edu. 6. Harvard Medical School, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA. avranceanu@mgh.harvard.edu.
Abstract
PURPOSE: To examine effects of a virtual mind-body group for adolescents with neurofibromatoses (NF1 and NF2; Resilient Youth withNeurofibromatosis; RY-NF) on multiple resiliency factors against a health education attention control (Health Education for Youth with Neurofibromatosis; HE-NF) using data from a randomized controlled trial. Specifically, our research question was whether adolescents randomized to the RY-NF (versus the HE-NF) would have greater improvements in resiliency factors at post-intervention and whether these gains would be maintained at 6-month follow-up. METHODS:Adolescents with NF (n = 51; M age 12-17) were randomly assigned to RY-NF (n = 27) or HE-NF (n = 24). Resiliency factors (mindfulness, coping, gratitude, optimism, and social support) were collected at baseline, post-intervention (88%), and 6-month follow-up (82%). RESULTS: Participation in the RY-NF was associated with greater pre-to-post improvements in gratitude (Mdifference = 4.38; 95% CI-0.52-8.23; p = .027) and mindfulness (Mdifference= 9.41; 95% CI 4.40-14.42.; p < .001) compared to HE-NF; improvements sustained at 6 months. There were no group differences on any additional resiliency factors. However, participation in the RY-NF was associated with pre-to-post- improvements in coping (Mdifference= 9.16; 95% CI 2.93-15.39; p = .005), and social support (Mdifference= 6.79; 95% CI 1.96-11.63; p = .007); improvements sustained at 6 months. CONCLUSIONS: Participation in the RY-NF resulted in sustained improvement in several resiliency factors. Promoting resiliency may help adolescents successfully navigate challenges associated with NF.
RCT Entities:
PURPOSE: To examine effects of a virtual mind-body group for adolescents with neurofibromatoses (NF1 and NF2; Resilient Youth with Neurofibromatosis; RY-NF) on multiple resiliency factors against a health education attention control (Health Education for Youth with Neurofibromatosis; HE-NF) using data from a randomized controlled trial. Specifically, our research question was whether adolescents randomized to the RY-NF (versus the HE-NF) would have greater improvements in resiliency factors at post-intervention and whether these gains would be maintained at 6-month follow-up. METHODS: Adolescents with NF (n = 51; M age 12-17) were randomly assigned to RY-NF (n = 27) or HE-NF (n = 24). Resiliency factors (mindfulness, coping, gratitude, optimism, and social support) were collected at baseline, post-intervention (88%), and 6-month follow-up (82%). RESULTS: Participation in the RY-NF was associated with greater pre-to-post improvements in gratitude (Mdifference = 4.38; 95% CI-0.52-8.23; p = .027) and mindfulness (Mdifference= 9.41; 95% CI 4.40-14.42.; p < .001) compared to HE-NF; improvements sustained at 6 months. There were no group differences on any additional resiliency factors. However, participation in the RY-NF was associated with pre-to-post- improvements in coping (Mdifference= 9.16; 95% CI 2.93-15.39; p = .005), and social support (Mdifference= 6.79; 95% CI 1.96-11.63; p = .007); improvements sustained at 6 months. CONCLUSIONS: Participation in the RY-NF resulted in sustained improvement in several resiliency factors. Promoting resiliency may help adolescents successfully navigate challenges associated with NF.
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