Joseph Gal1. 1. Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. joe.gal@ucdenver.edu.
Abstract
BACKGROUND: The stereochemical aspects of drugs are generally recognized as fundamentally important influencers of drug action and disposition. Nevertheless, the nonproprietary names of the vast majority of stereochemically relevant therapeutic agents in the USP Dictionary of United States Adopted Names (USAN) and International Drug Names and in the WHO Drug Information listings provide no information on the stereochemical aspects. OBJECTIVE: In view of the importance of stereochemistry in drug action and disposition, it is desirable to have a nonproprietary drug nomenclature system that provides basic information on the stereochemical identity and composition of drugs. METHODS: The USP Dictionary of USAN and International Drug Names, the WHO Drug Information listings, and the chemical literature were examined for stereochemical information on drugs as a basis for proposing a new stereochemically informative nonproprietary drug name system. RESULTS: A new system of stereochemically informative nonproprietary nomenclature system was designed that provides a "flag" alerting to the presence of stereochemical elements in the drug structure and includes basic information on the stereoisomerism of the drug. One of five prefixes would be added to the name: [dex]- (dextrorotatory single chiral stereoisomer); [lev]- (levorotatory single chiral stereoisomer); [rac]- (racemic mixture); [uni]-, (single achiral stereoisomer); and [mix]-, (mixture of stereoisomers other than racemic). CONCLUSIONS: The proposed system would be useful in the various domains of drug information, therapy, and research.
BACKGROUND: The stereochemical aspects of drugs are generally recognized as fundamentally important influencers of drug action and disposition. Nevertheless, the nonproprietary names of the vast majority of stereochemically relevant therapeutic agents in the USP Dictionary of United States Adopted Names (USAN) and International Drug Names and in the WHO Drug Information listings provide no information on the stereochemical aspects. OBJECTIVE: In view of the importance of stereochemistry in drug action and disposition, it is desirable to have a nonproprietary drug nomenclature system that provides basic information on the stereochemical identity and composition of drugs. METHODS: The USP Dictionary of USAN and International Drug Names, the WHO Drug Information listings, and the chemical literature were examined for stereochemical information on drugs as a basis for proposing a new stereochemically informative nonproprietary drug name system. RESULTS: A new system of stereochemically informative nonproprietary nomenclature system was designed that provides a "flag" alerting to the presence of stereochemical elements in the drug structure and includes basic information on the stereoisomerism of the drug. One of five prefixes would be added to the name: [dex]- (dextrorotatory single chiral stereoisomer); [lev]- (levorotatory single chiral stereoisomer); [rac]- (racemic mixture); [uni]-, (single achiral stereoisomer); and [mix]-, (mixture of stereoisomers other than racemic). CONCLUSIONS: The proposed system would be useful in the various domains of drug information, therapy, and research.