Geoffrey Ledoux1,2,3, Koceila Amroun3,4, Rami Rhaiem5,6,7, Audrey Cagniet1,2,3, Arman Aghaei1,2,3, Olivier Bouche2,3,8, Christine Hoeffel2,3,9, Daniele Sommacale1,2,3, Tullio Piardi1,2,3, Reza Kianmanesh1,2,3. 1. Department of HBP and Digestive Oncological Surgery, Robert Debré University- Hospital, Reims, France. 2. Reims Medical Faculty, Reims, France. 3. University of Reims Champagne Ardenne, Reims, France. 4. Department of Surgery, Jean Godinot Cancer Institute, Reims, France. 5. Department of HBP and Digestive Oncological Surgery, Robert Debré University- Hospital, Reims, France. rrhaiem@chu-reims.fr. 6. Reims Medical Faculty, Reims, France. rrhaiem@chu-reims.fr. 7. University of Reims Champagne Ardenne, Reims, France. rrhaiem@chu-reims.fr. 8. Deprtement of Oncology, Robert Debré University- Hospital, Reims, France. 9. Departement of Radiology, Robert Debré University- Hospital, Reims, France.
Abstract
BACKGROUND: The aim of this study was to analyze risk factors of local recurrence (LR) after exclusive laparoscopic thermo-ablation (TA) with or without associated liver resection. METHODS: Between 2012 and 2017, among 385 patients who underwent 820 TA in our department, 65 (17%) patients (HCC = 11, LM = 54) had exclusive laparoscopic TA representing 112 lesions (HCC = 17, LM = 95). TA was associated with other procedures in 57% of cases (liver resection 81%). All TA were done without liver clamping. Median tumor size was 1.8 cm [ranges from 0.3 to 4.5], 18% of the lesions were larger than 3 cm in size and 11% close to major liver vessels. Tumors locations were 77.5% in right liver, 36% in S7&S8, and 46% in S7&S8&S4a. RESULTS: Mortality was nil and morbidity rate 15.4% including Dindo-Clavien > II grade 3%. The median follow-up was 24 months [0.77-75]. Per lesion LR rate after TA was 18% (n = 19 patients) with a mean time of 7.6 months. Among patients with LR, 18 (95%) could have been re-treated successfully (new resection = 11, re-TA = 7). Multivariate analyses revealed that tumor location in S7 alone, S7&S8 and/or S7, S8, or S4a were independent risk factors of LR after TA. CONCLUSIONS: Exclusive laparoscopic TA is a safe and an effective tool to treat liver malignancies with or without liver resection. Other than classical risk factors, tumor location in upper segments of the liver, are independent risk factors for LR.
BACKGROUND: The aim of this study was to analyze risk factors of local recurrence (LR) after exclusive laparoscopic thermo-ablation (TA) with or without associated liver resection. METHODS: Between 2012 and 2017, among 385 patients who underwent 820 TA in our department, 65 (17%) patients (HCC = 11, LM = 54) had exclusive laparoscopic TA representing 112 lesions (HCC = 17, LM = 95). TA was associated with other procedures in 57% of cases (liver resection 81%). All TA were done without liver clamping. Median tumor size was 1.8 cm [ranges from 0.3 to 4.5], 18% of the lesions were larger than 3 cm in size and 11% close to major liver vessels. Tumors locations were 77.5% in right liver, 36% in S7&S8, and 46% in S7&S8&S4a. RESULTS: Mortality was nil and morbidity rate 15.4% including Dindo-Clavien > II grade 3%. The median follow-up was 24 months [0.77-75]. Per lesion LR rate after TA was 18% (n = 19 patients) with a mean time of 7.6 months. Among patients with LR, 18 (95%) could have been re-treated successfully (new resection = 11, re-TA = 7). Multivariate analyses revealed that tumor location in S7 alone, S7&S8 and/or S7, S8, or S4a were independent risk factors of LR after TA. CONCLUSIONS: Exclusive laparoscopic TA is a safe and an effective tool to treat liver malignancies with or without liver resection. Other than classical risk factors, tumor location in upper segments of the liver, are independent risk factors for LR.
Authors: Jonghun J Lee; John B Conneely; Rory L Smoot; Steven Gallinger; Paul D Greig; Carol-Anne Moulton; Alice Wei; Ian McGilvray; Sean P Cleary Journal: HPB (Oxford) Date: 2014-10-09 Impact factor: 3.647
Authors: S Rossi; E Buscarini; F Garbagnati; M Di Stasi; P Quaretti; M Rago; A Zangrandi; S Andreola; D Silverman; L Buscarini Journal: AJR Am J Roentgenol Date: 1998-04 Impact factor: 3.959
Authors: Robert M Cannon; Charles R Scoggins; Glenda G Callender; Amy Quillo; Kelly M McMasters; Robert C G Martin Journal: Ann Surg Oncol Date: 2013-05-01 Impact factor: 5.344
Authors: Martijn R Meijerink; Robbert S Puijk; Aukje A J M van Tilborg; Kirsten Holdt Henningsen; Llenalia Garcia Fernandez; Mattias Neyt; Juanita Heymans; Jacqueline S Frankema; Koert P de Jong; Dick J Richel; Warner Prevoo; Joan Vlayen Journal: Cardiovasc Intervent Radiol Date: 2018-04-17 Impact factor: 2.740
Authors: Matteo Renzulli; Nicolò Brandi; Anna Pecorelli; Luigi Vincenzo Pastore; Alessandro Granito; Giuseppe Martinese; Francesco Tovoli; Mario Simonetti; Elton Dajti; Antonio Colecchia; Rita Golfieri Journal: Diagnostics (Basel) Date: 2022-03-29