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Literature DB >> 32076781

Teicoplanin biosynthesis: unraveling the interplay of structural, regulatory, and resistance genes.

Oleksandr Yushchuk^1,2, Bohdan Ostash¹, Andrew W Truman³, Flavia Marinelli², Victor Fedorenko⁴.

Abstract

Teicoplanin (Tcp) is a clinically relevant glycopeptide antibiotic (GPA) that is produced by the actinobacterium Actinoplanes teichomyceticus. Tcp is a front-line therapy for treating severe infections caused by multidrug-resistant Gram-positive pathogens in adults and infants. In this review, we provide a detailed overview of how Tcp is produced by A. teichomyceticus by describing Tcp biosynthesis, regulation, and resistance. We summarize the knowledge gained from in vivo and in vitro studies to provide an integrated model of teicoplanin biosynthesis. Then, we discuss genetic and nutritional factors that contribute to the regulation of teicoplanin biosynthesis, focusing on those that have been successfully applied for improving teicoplanin production. A current view on teicoplanin self-resistance mechanisms in A. teichomyceticus is given, and we compare the Tcp biosynthetic gene cluster with other glycopeptide gene clusters from actinoplanetes and from unidentified isolates/metagenomics samples. Finally, we provide an outlook for further directions in studying Tcp biosynthesis and regulation.

Entities: Chemical

Keywords: Actinoplanes teichomyceticus; Glycopeptide antibiotics; Regulation; Teicoplanin; Teicoplanin biosynthesis; Teicoplanin resistance

Mesh：

Substances：

Year: 2020 PMID： 32076781 DOI： 10.1007/s00253-020-10436-y

Source DB: PubMed Journal: Appl Microbiol Biotechnol ISSN： 0175-7598 Impact factor: 5.560

65 in total

1. Resistance to glycopeptide antibiotics in the teicoplanin producer is mediated by van gene homologue expression directing the synthesis of a modified cell wall peptidoglycan.

Authors: Fabrizio Beltrametti; Arianna Consolandi; Lucia Carrano; Francesca Bagatin; Roberta Rossi; Livia Leoni; Elisabetta Zennaro; Enrico Selva; Flavia Marinelli
Journal: Antimicrob Agents Chemother Date: 2007-01-12 Impact factor: 5.191

2. Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine.

Authors: H Chen; C C Tseng; B K Hubbard; C T Walsh
Journal: Proc Natl Acad Sci U S A Date: 2001-12-18 Impact factor: 11.205

3. Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism.

Authors: Melanie Gonsior; Agnes Mühlenweg; Marcel Tietzmann; Saskia Rausch; Annette Poch; Roderich D Süssmuth
Journal: Chembiochem Date: 2015-10-30 Impact factor: 3.164

4. Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727.

Authors: Elisa Binda; Giorgia L Marcone; Loredano Pollegioni; Flavia Marinelli
Journal: FEBS J Date: 2012-08-02 Impact factor: 5.542

5. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.

Authors: H Chen; M G Thomas; B K Hubbard; H C Losey; C T Walsh; M D Burkart
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

6. Actaplanin, new glycopeptide antibiotics produced by Actinoplanes missouriensis. The isolation and preliminary chemical characterization of actaplanin.

Authors: M Debono; K E Merkel; R M Molloy; M Barnhart; E Presti; A H Hunt; R L Hamill
Journal: J Antibiot (Tokyo) Date: 1984-02 Impact factor: 2.649

7. The biosynthesis of teicoplanin-type glycopeptide antibiotics: assignment of p450 mono-oxygenases to side chain cyclizations of glycopeptide a47934.

Authors: Bianka Hadatsch; Diane Butz; Timo Schmiederer; Julia Steudle; Wolfgang Wohlleben; Roderich Süssmuth; Evi Stegmann
Journal: Chem Biol Date: 2007-09

8. Factors affecting the normal and branched-chain acyl moieties of teicoplanin components produced by Actinoplanes teichomyceticus.

Authors: A Borghi; D Edwards; L F Zerilli; G C Lancini
Journal: J Gen Microbiol Date: 1991-03

9. Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.

Authors: Jacob J Banik; Jeffrey W Craig; Paula Y Calle; Sean F Brady
Journal: J Am Chem Soc Date: 2010-11-10 Impact factor: 15.419

10. Magnetic Nanoconjugated Teicoplanin: A Novel Tool for Bacterial Infection Site Targeting.

Authors: Ilaria Armenia; Giorgia Letizia Marcone; Francesca Berini; Viviana Teresa Orlandi; Cristina Pirrone; Eleonora Martegani; Rosalba Gornati; Giovanni Bernardini; Flavia Marinelli
Journal: Front Microbiol Date: 2018-10-17 Impact factor: 5.640

6 in total

Review 1. Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches.

Authors: Pedro N Batalha; Luana S M Forezi; Carolina G S Lima; Fernanda P Pauli; Fernanda C S Boechat; Maria Cecília B V de Souza; Anna C Cunha; Vitor F Ferreira; Fernando de C da Silva
Journal: Bioorg Chem Date: 2020-11-19 Impact factor: 5.275

2. Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor.

Authors: Dylan J McClung; Yongle Du; Dominic J Antonich; Bailey Bonet; Wenjun Zhang; Matthew F Traxler
Journal: mBio Date: 2022-05-24 Impact factor: 7.786

6. Genomic Insights into the Distribution and Phylogeny of Glycopeptide Resistance Determinants within the Actinobacteria Phylum.

Authors: Andrés Andreo-Vidal; Elisa Binda; Victor Fedorenko; Flavia Marinelli; Oleksandr Yushchuk
Journal: Antibiotics (Basel) Date: 2021-12-14