| Literature DB >> 32076441 |
A Sebastian Lopez-Chiriboga1,2, Gregory Van Stavern3, Eoin P Flanagan1,2,4, Sean J Pittock1,2,4, Jim Fryer2,4, M Tariq Bhatti1,5, John J Chen1,5.
Abstract
Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.Entities:
Keywords: Optic perineuritis; aquaporin-4 (AQP4); myelin oligodendrocyte glycoprotein (MOG); optic nerve sheath; optic neuritis
Year: 2019 PMID: 32076441 PMCID: PMC6999618 DOI: 10.1080/01658107.2019.1607883
Source DB: PubMed Journal: Neuroophthalmology ISSN: 0165-8107