| Literature DB >> 32075736 |
Marta Giovanetti1, Nuno Rodrigues Faria2, José Lourenço3, Jaqueline Goes de Jesus4, Joilson Xavier5, Ingra Morales Claro6, Moritz U G Kraemer3, Vagner Fonseca7, Simon Dellicour8, Julien Thézé3, Flavia da Silva Salles6, Tiago Gräf9, Paola Paz Silveira9, Valdinete Alves do Nascimento10, Victor Costa de Souza10, Felipe Campos de Melo Iani11, Emerson Augusto Castilho-Martins12, Laura Nogueira Cruz13, Gabriel Wallau14, Allison Fabri4, Flávia Levy4, Joshua Quick15, Vasco de Azevedo5, Renato Santana Aguiar9, Tulio de Oliveira16, Camila Bôtto de Menezes17, Marcia da Costa Castilho18, Tirza Matos Terra19, Marineide Souza da Silva19, Ana Maria Bispo de Filippis4, André Luiz de Abreu13, Wanderson Kleber Oliveira20, Julio Croda21, Carlos F Campelo de Albuquerque22, Marcio R T Nunes23, Ester Cerdeira Sabino6, Nicholas Loman15, Felipe Gomes Naveca10, Oliver G Pybus24, Luiz Carlos Alcantara25.
Abstract
Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.Entities:
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Year: 2020 PMID： 32075736 DOI： 10.1016/j.celrep.2020.01.085
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423