Literature DB >> 3207554

Passage of chloroquine into semen.

E I Ette1, J I Ogonor, E E Essien.   

Abstract

The passage of chloroquine into semen was investigated in four healthy men following the oral administration of four chloroquine sulphate tablets (600 mg base) to each subject. Chloroquine was found to be excreted into semen with a slow transfer rate constant of 0.0002 min-1, and the semen/plasma ratio based on regression analysis was 0.40 +/- 0.06 (mean +/- s.d.). It is concluded that the passage of chloroquine from plasma to semen occurs by passive diffusion.

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Year:  1988        PMID： 3207554      PMCID： PMC1386525          DOI： 10.1111/j.1365-2125.1988.tb03384.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  20 in total

1.  Letter: Possible sensitivity to vinblastine in prostatic or seminal fluid.

Authors:  W J Paladine; T J Cunningham; M A Donavan; C W Dumper
Journal:  N Engl J Med       Date:  1975-01-02       Impact factor: 91.245

2.  THE OTOTOXICITY OF CHLOROQUINE PHOSPHATE.

Authors:  C W HART; R F NAUNTON
Journal:  Arch Otolaryngol       Date:  1964-10

3.  Absorption of drugs from the stomach. II. The human.

Authors:  C A HOGBEN; L S SCHANKER; D J TOCCO; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1957-08       Impact factor: 4.030

4.  Absorption of drugs from the rat small intestine.

Authors:  L S SCHANKER; D J TOCCO; B B BRODIE; C A HOGBEN
Journal:  J Pharmacol Exp Ther       Date:  1958-05       Impact factor: 4.030

5.  Malaria associated with pregnancy.

Authors:  R Lewis; N H Lauersen; S Birnbaum
Journal:  Obstet Gynecol       Date:  1973-11       Impact factor: 7.661

6.  Seminal fluid and plasma prostaglandin responses to aspirin in normal subjects.

Authors:  W Jubiz; J Frailey
Journal:  Fertil Steril       Date:  1973-12       Impact factor: 7.329

7.  A quantitative study of the effects of acetylsalicylic acid on spermatogenesis and organs of the rat.

Authors:  J E Scott; T V Persaud
Journal:  Int J Fertil       Date:  1978

8.  Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria.

Authors:  O Walker; A H Dawodu; A A Adeyokunnu; L A Salako; G Alvan
Journal:  Br J Clin Pharmacol       Date:  1983-12       Impact factor: 4.335

9.  Properties of phospholipase C isolated from rat liver lysosomes.

Authors:  Y Matsuzawa; K Y Hostetler
Journal:  J Biol Chem       Date:  1980-01-25       Impact factor: 5.157

10.  Effects of chloroquine and 4,4'-bis(diethylaminoethoxy)alpha, beta-diethyldiphenylethane on the incorporation of [3H]glycerol into the phospholipids of rat liver lysosomes and other subcellular fractions, in vivo.

Authors:  Y Matsuzawa; K Y Hostetler
Journal:  Biochim Biophys Acta       Date:  1980-12-05
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  4 in total

Review 1.  Drugs in semen.

Authors:  S Pichini; P Zuccaro; R Pacifici
Journal:  Clin Pharmacokinet       Date:  1994-05       Impact factor: 6.447

2.  A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial Spiroindolone KAE609 (Cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.

Authors:  F Joel Leong; Ruobing Li; Jay Prakash Jain; Gilbert Lefèvre; Baldur Magnusson; Thierry T Diagana; Peter Pertel
Journal:  Antimicrob Agents Chemother       Date:  2014-08-11       Impact factor: 5.191

Review 3.  FIRST REPORTS OF CLINICAL PHARMACOKINETICS IN NIGERIA.

Authors:  O S Michael
Journal:  Ann Ib Postgrad Med       Date:  2015-06

4.  The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review.

Authors:  L F Perez-Garcia; R J E M Dolhain; S Vorstenbosch; W Bramer; E van Puijenbroek; J M W Hazes; B Te Winkel
Journal:  Hum Reprod Update       Date:  2020-11-01       Impact factor: 15.610
  4 in total

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