Literature DB >> 32074695

[Concern about lung damage caused by guanidine cationic disinfectants].

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Abstract

This article summarized the use of guanidine disinfectants in China and the use of guanidine cationic disinfectants, polyhexamethylene guanidine (PHMG), in South Korea, which had caused severe lung damage events such as pulmonary fibrosis. The authors reviewed the studies that Chinese scientists employed ultrasonic atomization technology to simulate the actual scenario of human exposure to PHMG and proved the findings that PHMG could cause pulmonary fibrosis. These results could highlight the necessity of full attention to lung damage caused by guanidine disinfectants and its mechanism, so as to provide the important scientific basis for the protection of public health safety and the formulation of corresponding policies.

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Keywords:  Disinfectant; Guanidines; Lung injury

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Year:  2020        PMID: 32074695     DOI: 10.3760/cma.j.issn.0253-9624.2020.02.001

Source DB:  PubMed          Journal:  Zhonghua Yu Fang Yi Xue Za Zhi        ISSN: 0253-9624


  1 in total

1.  The liver X receptor agonist T0901317 reduces the inflammation of alveolar epithelial cells induced by polyhexamethylene guanidine through inhibition of the NFκB signaling pathway.

Authors:  Lutang Wei; Yongzhong Guo; Xiaoqian Ding; Caihong Guo; Nan Ge; Dunqiang Ren; Hongmei Wang
Journal:  Ann Transl Med       Date:  2021-12
  1 in total

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