Literature DB >> 3207427

Azidothymidine inhibits mitogen stimulated growth and DNA-repair in human peripheral lymphocytes.

B Munch-Petersen1.   

Abstract

Until now, 3'-Azido-3'-deoxythymidine (AZT) is the most widely used drug in AIDS therapy, but the positive anti HIV effect of the drug is often accompanied by severe side effects such as bone-marrow suppression. In the present study, the effect of AZT on UV induced DNA strand-break rejoining and on phytohemagglutinin stimulated growth of lymphocytes from 7 healthy volunteers has been examined, and inhibitory effects of the drug was observed at therapeutic concentrations, i.e. 1-10 uM AZT.

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Year:  1988        PMID： 3207427     DOI： 10.1016/s0006-291x(88)81026-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  Evidence that high-dosage zidovudine at time of retrovirus exposure reduces antiviral efficacy.

Authors:  L E Mathes; K A Hayes; G Kociba
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

2.  Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells.

Authors:  R E Dornsife; M H St Clair; A T Huang; T J Panella; G W Koszalka; C L Burns; D R Averett
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

3.  Nuclear and mitochondrial changes of muscle fibers in AIDS after treatment with high doses of zidovudine.

Authors:  J M Schröder; M Bertram; R Schnabel; U Pfaff
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

4.  Inhibitory effect of 3'-azido-3'-deoxythymidine on proliferative responsiveness of CD8+ lymphocytes to interleukin-2.

Authors:  L Mercure; R Lalonde; D Phaneuf; B Brenner; M A Wainberg
Journal:  Clin Diagn Lab Immunol       Date:  1994-07
  4 in total

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