Literature DB >> 32072913

Syringic Acid: A Potential Natural Compound for the Management of Renal Oxidative Stress and Mitochondrial Biogenesis in Diabetic Rats.

Marzieh Rashedinia1, Mohammad Javad Khoshnoud1, Bahman Khalvati Fahlyan2, Seyedeh-Sara Hashemi3, Mahshid Alimohammadi1, Zahra Sabahi4.   

Abstract

BACKGROUND: Diabetic nephropathy can lead to renal diseases; oxidative stress and mitochondrial dysfunction have critical roles in its development.
OBJECTIVES: In this study, the effect of syringic acid (SYR), a natural phenolic acid, on diabetic nephropathy and mitochondrial biogenesis was examined.
METHODS: Diabetes was induced in rats by injecting streptozotocin. SYR (25, 50 and 100 mg/kg/day) was orally administered for 6 weeks. SYR effects on factors, such as antioxidant activities and mRNA expression level of mitochondrial biogenesis indexes, were evaluated.
RESULTS: In SYR-treated rats, blood glucose and ALP level were significantly reduced. SYR increased kidney GSH content in the diabetic group. Elevated renal catalase and superoxide dismutase activities in diabetic rats were restored to normal levels after treatment. SYR significantly reduced the renal TBARS level, which had increased in diabetic rats. This compound also significantly upregulated renal mRNA expression of PGC-1α and NRF-1, and increased mtDNA/nDNA ratio in diabetic rats. These values were reduced in the non-treated diabetic group. The results show improvement of histopathological damages of kidney in the SYR treated group in comparison with the diabetic group.
CONCLUSION: According to the results, SYR alters renal antioxidant defense mechanisms. Also, it could be considered as a novel approach by targeting mitochondria in renal diabetic complications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Syringic acid; biogenesis; diabetes; mitochondrial dysfunction.; nephropathy; oxidative stress

Mesh：

Substances：

Year:  2021        PMID： 32072913     DOI： 10.2174/1570163817666200211101228

Source DB:  PubMed          Journal:  Curr Drug Discov Technol        ISSN： 1570-1638


  9 in total

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Journal:  3 Biotech       Date:  2022-04-11       Impact factor: 2.893

2.  Neuroprotective Effect of Syringic Acid by Modulation of Oxidative Stress and Mitochondrial Mass in Diabetic Rats.

Authors:  Marzieh Rashedinia; Mahshid Alimohammadi; Nazgol Shalfroushan; Mohammad Javad Khoshnoud; Mitra Mansourian; Negar Azarpira; Zahra Sabahi
Journal:  Biomed Res Int       Date:  2020-12-04       Impact factor: 3.411

3.  Syringic Acid Attenuates Cardiomyopathy in Streptozotocin-Induced Diabetic Rats.

Authors:  Zahra Sabahi; Mohammad Javad Khoshnoud; Sara Hosseini; Fatemeh Khoshraftar; Marzieh Rashedinia
Journal:  Adv Pharmacol Pharm Sci       Date:  2021-12-28

4.  Effect of ethanolic extract of Stachys pilifera Benth on subacute experimental models of inflammation and some underlying mechanisms.

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Journal:  Res Pharm Sci       Date:  2021-08-19

5.  Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats.

Authors:  Zahra Moslemi; Hassan Bardania; Izadpanah Gheitasi; Zahra Barmoudeh; Navid Omidifar; Hamidreza Parvin; Bahman Khalvati; Mohamad Hassan Fouani; Mohsen Alipour; Amir Hossein Doustimotlagh
Journal:  Oxid Med Cell Longev       Date:  2021-10-18       Impact factor: 6.543

6.  Syringic and ascorbic acids prevent NDMA-induced pulmonary fibrogenesis, inflammation, apoptosis, and oxidative stress through the regulation of PI3K-Akt/PKB-mTOR-PTEN signaling pathway.

Authors:  Oluwatobi T Somade; Olubisi E Adeyi; Babajide O Ajayi; Osiro O Asunde; Precious D Iloh; Adedayo A Adesanya; Olanrewaju I Babalola; Oluwaseyi T Folorunsho; Deborah A Olakunle; Opeyemi F Lawal
Journal:  Metabol Open       Date:  2022-03-17

Review 7.  Macrophage Polarization Mediated by Mitochondrial Dysfunction Induces Adipose Tissue Inflammation in Obesity.

Authors:  Long Xu; Xiaoyu Yan; Yuanxin Zhao; Jian Wang; Buhan Liu; Sihang Yu; Jiaying Fu; Yanan Liu; Jing Su
Journal:  Int J Mol Sci       Date:  2022-08-17       Impact factor: 6.208

8.  Syringic Acid Ameliorates Cardiac, Hepatic, Renal and Neuronal Damage Induced by Chronic Hyperglycaemia in Wistar Rats: A Behavioural, Biochemical and Histological Analysis.

Authors:  Anwarbaig C Mirza; Shital S Panchal; Ahmed A Allam; Sarah I Othman; Milan Satia; Sanjay N Mandhane
Journal:  Molecules       Date:  2022-10-09       Impact factor: 4.927

9.  The Effect of a Traditional Preparation Containing Piper nigrum L. and Bunium persicum (Boiss.) B.Fedtsch. on Immobility Stress-Induced Memory Loss in Mice.

Authors:  Marzieh Rashedinia; Mina Mojarad; Forouzan Khodaei; Ali Sahragard; Mohammad Javad Khoshnoud; Mohammad M Zarshenas
Journal:  Biomed Res Int       Date:  2021-06-12       Impact factor: 3.411
  9 in total

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