Jamal Rahmani1, Hamed Kord Varkaneh2, Vasileios Kontogiannis3, Paul M Ryan4, Hiba Bawadi5, Somaye Fatahi6, Yong Zhang7. 1. aDepartment of Community Nutrition, Student Research Committee, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. bStudents' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran, Tehran, Iran. 3. cInstitute of Health & Society, Newcastle University, Newcastle upon Tyne, United Kingdom. 4. dSchool of Medicine, University College Cork, Cork, Ireland. 5. eDepartment of Human Nutrition, College of Health Sciences, QU-Health, Qatar University, Doha, Qatar. 6. fStudent Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. 7. gSchool of Public Health and Health Management, Chongqing Medical University, Chongqing, China.
Abstract
PURPOSE: Liver cancer is the sixth most common type of cancer worldwide, and waist circumference (WC) is associated with its risk beyond body mass index (BMI). This dose-response meta-analysis was performed to investigate the association between WC and the risk of incident liver cancer using prospective cohort studies. METHODS: A comprehensive systematic search was conducted in MEDLINE/PubMed, Web of Science databases, Scopus, and Coch-rane from inception to May 2019. Studies with retrospective or prospective cohort design that reported hazard ratio (HR), risk ratio, or odds ratio, and the corresponding 95% confidence intervals (CI) for liver cancer based on WC categories were included in this meta-analysis. Combined HRs with 95% CIs was estimated by DerSimonian and Laird random-effects models. RESULTS: Associations between WC and liver cancer were reported in 5 articles with 2,547,188 participants. All studies were published between 2013 and 2019. Pooled results showed a strong significant association with minimum heterogeneity between WC and risk of liver cancer (HR 1.59, 95% CI 1.38-1.83, p<sub>heterogeneity</sub> = 0.42: I<sup>2</sup> = 0%). Moreover, a dose-response model indicated a significant positive association between WC and risk of liver cancer (exp(b) = 1.018, p < 0.001). CONCLUSIONS: This systematic review and dose-response meta-analysis highlights WC as a significant risk factor related to the incidence of liver cancer.
PURPOSE: Liver cancer is the sixth most common type of cancer worldwide, and waist circumference (WC) is associated with its risk beyond body mass index (BMI). This dose-response meta-analysis was performed to investigate the association between WC and the risk of incident liver cancer using prospective cohort studies. METHODS: A comprehensive systematic search was conducted in MEDLINE/PubMed, Web of Science databases, Scopus, and Coch-rane from inception to May 2019. Studies with retrospective or prospective cohort design that reported hazard ratio (HR), risk ratio, or odds ratio, and the corresponding 95% confidence intervals (CI) for liver cancer based on WC categories were included in this meta-analysis. Combined HRs with 95% CIs was estimated by DerSimonian and Laird random-effects models. RESULTS: Associations between WC and liver cancer were reported in 5 articles with 2,547,188 participants. All studies were published between 2013 and 2019. Pooled results showed a strong significant association with minimum heterogeneity between WC and risk of liver cancer (HR 1.59, 95% CI 1.38-1.83, p<sub>heterogeneity</sub> = 0.42: I<sup>2</sup> = 0%). Moreover, a dose-response model indicated a significant positive association between WC and risk of liver cancer (exp(b) = 1.018, p < 0.001). CONCLUSIONS: This systematic review and dose-response meta-analysis highlights WC as a significant risk factor related to the incidence of liver cancer.
Authors: Libby M Morimoto; Emily White; Z Chen; Rowan T Chlebowski; Jennifer Hays; Lewis Kuller; Ana Marie Lopez; JoAnn Manson; Karen L Margolis; Paola C Muti; Marcia L Stefanick; Anne McTiernan Journal: Cancer Causes Control Date: 2002-10 Impact factor: 2.506
Authors: D F Stroup; J A Berlin; S C Morton; I Olkin; G D Williamson; D Rennie; D Moher; B J Becker; T A Sipe; S B Thacker Journal: JAMA Date: 2000-04-19 Impact factor: 56.272
Authors: Frank E Corrigan; Heval Mohamed Kelli; Devinder S Dhindsa; Robert E Heinl; Ibhar Al Mheid; Muhammad Hammadah; Salim S Hayek; Salman Sher; Danny J Eapen; Greg S Martin; Arshed A Quyyumi Journal: J Clin Lipidol Date: 2017-09-01 Impact factor: 5.365
Authors: Luopei Wei; Ni Li; Gang Wang; Xiaoshuang Feng; Zhangyan Lyu; Xin Li; Yan Wen; Yuheng Chen; Hongda Chen; Shuohua Chen; Shouling Wu; Min Dai; Jie He Journal: Front Oncol Date: 2018-12-12 Impact factor: 6.244