Adam Evans1, Maryo Ibrahim1, Rand Pope2, James Mwangi1, Mina Botros1, Shepard P Johnson3, Salam Al Kassis3. 1. Meharry Medical College, 1005 Dr DB Todd Jr Blvd, Nashville, TN, 37208, USA. 2. Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN, 37232, USA. 3. Vanderbilt University Medical Center Department of Plastic Surgery, D-4207 Medical Center North, 1211 Medical Center Drive, Nashville, TN, 37212, USA.
Abstract
BACKGROUND: This study summarizes all literature investigating platelet-rich plasma (PRP) in the treatment of osteoarthritis of the hands and feet. MATERIALS & METHODS: This is a PRISMA compliant systematic review of 7 databases and includes a meta-analysis of randomized controlled trial (RCT) data on pain and function. RESULTS: Nine articles were included in the review. Meta-analysis of 4 RCTs shows PRP significantly improves pain and function versus control. More results are significant at longer duration follow-up. CONCLUSIONS: PRP improves pain and function of osteoarthritis. Heterogeneity and risk-of-bias limit current data, requiring more RCTs to determine any regenerative potential of PRP. PROSPERO SYSTEMATIC REVIEW REGISTRATION NUMBER: 136582.
BACKGROUND: This study summarizes all literature investigating platelet-rich plasma (PRP) in the treatment of osteoarthritis of the hands and feet. MATERIALS & METHODS: This is a PRISMA compliant systematic review of 7 databases and includes a meta-analysis of randomized controlled trial (RCT) data on pain and function. RESULTS: Nine articles were included in the review. Meta-analysis of 4 RCTs shows PRP significantly improves pain and function versus control. More results are significant at longer duration follow-up. CONCLUSIONS: PRP improves pain and function of osteoarthritis. Heterogeneity and risk-of-bias limit current data, requiring more RCTs to determine any regenerative potential of PRP. PROSPERO SYSTEMATIC REVIEW REGISTRATION NUMBER: 136582.
Authors: Ulrich Nöth; Lars Rackwitz; Andrea Heymer; Meike Weber; Bernd Baumann; Andre Steinert; Norbert Schütze; Franz Jakob; Jochen Eulert Journal: J Biomed Mater Res A Date: 2007-12-01 Impact factor: 4.396
Authors: Gerben M van Buul; Wendy L M Koevoet; Nicole Kops; P Koen Bos; Jan A N Verhaar; Harrie Weinans; Monique R Bernsen; Gerjo J V M van Osch Journal: Am J Sports Med Date: 2011-08-19 Impact factor: 6.202
Authors: Jessica Intravia; Donald A Allen; Thomas Js Durant; Mary Beth R McCarthy; Ryan Russell; Knut Beitzel; Mark P Cote; Feliciano Dias; Augustus D Mazzocca Journal: Muscles Ligaments Tendons J Date: 2014-05-08
Authors: E Anitua; M Sánchez; A T Nurden; M M Zalduendo; M de la Fuente; J Azofra; I Andía Journal: Rheumatology (Oxford) Date: 2007-10-17 Impact factor: 7.580
Authors: Adam G Evans; Mirjana G Ivanic; Mina A Botros; Rand W Pope; Briana R Halle; Gabriella E Glassman; Rafaella Genova; Salam Al Kassis Journal: Arch Dermatol Res Date: 2021-01-12 Impact factor: 3.017
Authors: Li Bocun; Li Jing; Li Jia; Qian Tan; Jianyi Chen; Zhongsheng Huang; Cai Guowei Journal: Medicine (Baltimore) Date: 2021-01-08 Impact factor: 1.817