Literature DB >> 32071056

Genomic Characterization of Neisseria gonorrhoeae Strains from 2016 U.S. Sentinel Surveillance Displaying Reduced Susceptibility to Azithromycin.

Matthew W Schmerer1, A Jeanine Abrams2, Sandra Seby2,3, Jesse C Thomas2,3, John Cartee2,3, Sean Lucking2,3, Eshaw Vidyaprakash2,3, Cau D Pham2, Samera Sharpe2, Kevin Pettus2, Sancta B St Cyr2, Elizabeth A Torrone2, Ellen N Kersh2, Kim M Gernert2.   

Abstract

In 2016, the proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to azithromycin rose to 3.6%. A phylogenetic analysis of 334 N. gonorrhoeae isolates collected in 2016 revealed a single, geographically diverse lineage of isolates with MICs of 2 to 16 μg/ml that carried a mosaic-like mtr locus, whereas the majority of isolates with MICs of ≥16 μg/ml appeared sporadically and carried 23S rRNA mutations. Continued molecular surveillance of N. gonorrhoeae isolates will identify new resistance mechanisms.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  23S rRNA; Neisseria gonorrhoeaezzm321990; antimicrobial resistance; azithromycin; mosaic-like mtrRzzm321990

Mesh：

Substances：

Year:  2020        PMID： 32071056      PMCID： PMC7179607          DOI： 10.1128/AAC.02420-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in Neisseria gonorrhoeae.

Authors:  Crista B Wadsworth; Mohamad R A Sater; Roby P Bhattacharyya; Yonatan H Grad
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  High-level azithromycin resistance occurs in Neisseria gonorrhoeae as a result of a single point mutation in the 23S rRNA genes.

Authors:  Stephanie A Chisholm; Jayshree Dave; Catherine A Ison
Journal:  Antimicrob Agents Chemother       Date:  2010-06-28       Impact factor: 5.191

3.  Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California.

Authors:  Severin O Gose; Olusegun O Soge; James L Beebe; Duylinh Nguyen; Juliet E Stoltey; Heidi M Bauer
Journal:  Sex Transm Dis       Date:  2015-05       Impact factor: 2.830

4.  Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014-2016.

Authors:  Jesse C Thomas; Sandra Seby; A Jeanine Abrams; Jack Cartee; Sean Lucking; Eshaw Vidyaprakash; Matthew Schmerer; Cau D Pham; Jaeyoung Hong; Elizabeth Torrone; Sancta St Cyr; William M Shafer; Kyle Bernstein; Ellen N Kersh; Kim M Gernert
Journal:  J Infect Dis       Date:  2019-06-19       Impact factor: 5.226

5.  Decline in Decreased Cephalosporin Susceptibility and Increase in Azithromycin Resistance in Neisseria gonorrhoeae, Canada.

Authors:  I Martin; P Sawatzky; G Liu; V Allen; B Lefebvre; L Hoang; S Drews; G Horsman; J Wylie; D Haldane; R Garceau; S Ratnam; T Wong; C Archibald; M R Mulvey
Journal:  Emerg Infect Dis       Date:  2016-01       Impact factor: 6.883

6.  Azithromycin Resistance and Decreased Ceftriaxone Susceptibility in Neisseria gonorrhoeae, Hawaii, USA.

Authors:  John R Papp; A Jeanine Abrams; Evelyn Nash; Alan R Katz; Robert D Kirkcaldy; Norman P O'Connor; Pamela S O'Brien; Derek H Harauchi; Eloisa V Maningas; Olusegun O Soge; Ellen N Kersh; Alan Komeya; Juval E Tomas; Glenn M Wasserman; Gail Y Kunimoto; David L Trees; A Christian Whelen
Journal:  Emerg Infect Dis       Date:  2017-05       Impact factor: 6.883

7.  Increasing Resistance to Azithromycin in Neisseria gonorrhoeae in Eastern Chinese Cities: Resistance Mechanisms and Genetic Diversity among Isolates from Nanjing.

Authors:  Chuan Wan; Yang Li; Wen-Jing Le; Yu-Rong Liu; Sai Li; Bao-Xi Wang; Peter A Rice; Xiao-Hong Su
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

8.  Overall Low Extended-Spectrum Cephalosporin Resistance but high Azithromycin Resistance in Neisseria gonorrhoeae in 24 European Countries, 2015.

Authors:  Michelle J Cole; Gianfranco Spiteri; Susanne Jacobsson; Neil Woodford; Francesco Tripodo; Andrew J Amato-Gauci; Magnus Unemo
Journal:  BMC Infect Dis       Date:  2017-09-11       Impact factor: 3.090

9.  Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus.

Authors:  Corinne E Rouquette-Loughlin; Jennifer L Reimche; Jacqueline T Balthazar; Vijaya Dhulipala; Kim M Gernert; Ellen N Kersh; Cau D Pham; Kevin Pettus; A Jeanine Abrams; David L Trees; Sancta St Cyr; William M Shafer
Journal:  mBio       Date:  2018-11-27       Impact factor: 7.867

10.  Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.

Authors:  Crista B Wadsworth; Brian J Arnold; Mohamad R Abdul Sater; Yonatan H Grad
Journal:  mBio       Date:  2018-08-07       Impact factor: 7.867
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  7 in total

1.  Global Emergence and Dissemination of Neisseria gonorrhoeae ST-9363 Isolates with Reduced Susceptibility to Azithromycin.

Authors:  Sandeep J Joseph; Jesse C Thomas; Matthew W Schmerer; John C Cartee; Sancta St Cyr; Karen Schlanger; Ellen N Kersh; Brian H Raphael; Kim M Gernert
Journal:  Genome Biol Evol       Date:  2022-01-04       Impact factor: 3.416

2.  Phylogenomic Comparison of Neisseria gonorrhoeae Causing Disseminated Gonococcal Infections and Uncomplicated Gonorrhea in Georgia, United States.

Authors:  John C Cartee; Sandeep J Joseph; Emily Weston; Cau D Pham; Jesse C Thomas; Karen Schlanger; Sancta B St Cyr; Monica M Farley; Ashley E Moore; Amy K Tunali; Charletta Cloud; Brian H Raphael
Journal:  Open Forum Infect Dis       Date:  2022-05-13       Impact factor: 4.423

3.  Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.

Authors:  Grace A Beggs; Julio C Ayala; Logan G Kavanaugh; Timothy D Read; Grace M Hooks; Maria A Schumacher; William M Shafer; Richard G Brennan
Journal:  Nucleic Acids Res       Date:  2021-04-19       Impact factor: 16.971

4.  A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch.

Authors:  Leonor Sánchez-Busó; Corin A Yeats; Benjamin Taylor; Richard J Goater; Anthony Underwood; Khalil Abudahab; Silvia Argimón; Kevin C Ma; Tatum D Mortimer; Daniel Golparian; Michelle J Cole; Yonatan H Grad; Irene Martin; Brian H Raphael; William M Shafer; Katy Town; Teodora Wi; Simon R Harris; Magnus Unemo; David M Aanensen
Journal:  Genome Med       Date:  2021-04-19       Impact factor: 11.117

5.  Increasing Azithromycin Resistance in Neisseria gonorrhoeae Due to NG-MAST 12302 Clonal Spread in Canada, 2015 to 2018.

Authors:  Pam Sawatzky; Walter Demczuk; Brigitte Lefebvre; Vanessa Allen; Mathew Diggle; Linda Hoang; Paul Van Caeseele; David Haldane; Jessica Minion; Michael R Mulvey; Irene Martin
Journal:  Antimicrob Agents Chemother       Date:  2022-01-03       Impact factor: 5.191

6.  Evidence of Horizontal Gene Transfer of 50S Ribosomal Genes rplB, rplD, and rplY in Neisseria gonorrhoeae.

Authors:  Sheeba Santhini Manoharan-Basil; Jolein Gyonne Elise Laumen; Christophe Van Dijck; Tessa De Block; Irith De Baetselier; Chris Kenyon
Journal:  Front Microbiol       Date:  2021-06-10       Impact factor: 5.640

Review 7.  Bioinformatics tools used for whole-genome sequencing analysis of Neisseria gonorrhoeae: a literature review.

Authors:  Reema Singh; Anthony Kusalik; Jo-Anne R Dillon
Journal:  Brief Funct Genomics       Date:  2022-04-11       Impact factor: 4.840
  7 in total

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