Chunmei Guo1, Pei Qin2, Quanman Li1, Dongdong Zhang1, Gang Tian1, Dechen Liu1, Leilei Liu1, Cheng Cheng1, Xu Chen1, Ranran Qie1, Minghui Han1, Shengbing Huang1, Qionggui Zhou2, Feiyan Liu2, Xiaoyan Wu2, Yang Zhao1, Yongcheng Ren1, Yu Liu3, Xizhuo Sun3, Honghui Li3, Bingyuan Wang4, Ming Zhang2, Jie Lu5, Dongsheng Hu6. 1. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. 2. Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. 3. The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. 4. The Central China Fuwai Cardiovascular Research Center, Zhengzhou, Henan, People's Republic of China. 5. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: hanyaa800@zzu.edu.cn. 6. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. Electronic address: dongshenghu563@126.com.
Abstract
AIMS: Limited evidence is available on the association of mean arterial pressure and risk of type 2 diabetes mellitus (T2DM) among Chinese people. We aimed to investigate the association between MAP and risk of T2DM in rural Chinese adults. METHODS: We performed a cohort study of 12,284 eligible participants (4668 men and 7616 women) without T2DM at baseline. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of MAP with risk of T2DM. Restricted cubic spline models were used to evaluate the dose-response association between MAP and risk of T2DM. RESULTS: During a median of 6.01 years follow-up (73,403.52 person-years), T2DM developed in 847 participants (318 men and 529 women). In the multivariable-adjusted models, risk of T2DM was significantly higher for women with the third (90-100mmHg) and fourth MAP categories (≥100mmHg) than the first category (<80mmHg) after adjusting for confounders (HR=1.74 [95% CI 1.14-2.68] and 1.84 [1.20-2.83]). Restricted cubic spline analysis revealed increased risk of T2DM with increasing MAP for women. CONCLUSION: High MAP was related to high incident T2DM among women in China.
AIMS: Limited evidence is available on the association of mean arterial pressure and risk of type 2 diabetes mellitus (T2DM) among Chinese people. We aimed to investigate the association between MAP and risk of T2DM in rural Chinese adults. METHODS: We performed a cohort study of 12,284 eligible participants (4668 men and 7616 women) without T2DM at baseline. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of MAP with risk of T2DM. Restricted cubic spline models were used to evaluate the dose-response association between MAP and risk of T2DM. RESULTS: During a median of 6.01 years follow-up (73,403.52 person-years), T2DM developed in 847 participants (318 men and 529 women). In the multivariable-adjusted models, risk of T2DM was significantly higher for women with the third (90-100mmHg) and fourth MAP categories (≥100mmHg) than the first category (<80mmHg) after adjusting for confounders (HR=1.74 [95% CI 1.14-2.68] and 1.84 [1.20-2.83]). Restricted cubic spline analysis revealed increased risk of T2DM with increasing MAP for women. CONCLUSION: High MAP was related to high incident T2DM among women in China.