Edson Luiz Cetira Filho1, Francisco Samuel Rodrigues Carvalho2, Paulo Goberlânio de Barros Silva3, Daniel Almeida Ferreira Barbosa4, Karuza Maria Alves Pereira1, Thyciana Rodrigues Ribeiro5, Fábio Wildson Gurgel Costa6. 1. Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. 2. Division of Oral and Maxillofacial Surgery, Federal University of Ceará Campus Sobral, Sobral, CE, Brazil. Electronic address: samuel.rcarvalho@gmail.com. 3. UNICHRISTUS, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. 4. Paulo Picanço University, Postgraduate Student, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. 5. Division of Patients with Special Needs, Department of Clinical Dentistry, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil. 6. Division of Oral Radiology, Department of Clinical Dentistry, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil.
Abstract
PURPOSE: To investigate the effectiveness of preemptive analgesia with nonsteroidal anti-inflammatory drugs (NSAIDs) for the relief of inflammatory events (pain, edema, and trismus) after surgical removal of third molars. MATERIALS AND METHODS: A two-phase PROSPERO-registered systematic review was conducted in accordance with the PRISMA statement. PubMed, Scopus, Web of Science, COCHRANE, LILACS, DOSS, and gray literature were searched using the following terms (MeSH) or their combinations: molar, third; anti-inflammatory agents, non-steroidal; analgesia; preoperative period; pain management. RESULTS: From a total of 2903 articles, 31 (n = 2184 subjects) were selected. All studies presented a low risk of bias but exhibited high heterogeneity in methodology. Ten studies were selected for the meta-analysis. Preemptive analgesia for removal of third molars reduced average pain scores, especially those 1 h and 6 h after surgery (n = 151, p < 0.001, 95% CI = -2.81 to -0.97), reduced the average consumption of medication, and decreased the number of patients requiring medication without affecting the average time for its first consumption. CONCLUSION: In summary, most NSAIDs showed good results for inflammatory events and reduced average pain scores and consumption of rescue medication. However, more homogeneous and well-delineated clinical studies are necessary to determine a possible association between NSAIDs and the relief of inflammatory events.
PURPOSE: To investigate the effectiveness of preemptive analgesia with nonsteroidal anti-inflammatory drugs (NSAIDs) for the relief of inflammatory events (pain, edema, and trismus) after surgical removal of third molars. MATERIALS AND METHODS: A two-phase PROSPERO-registered systematic review was conducted in accordance with the PRISMA statement. PubMed, Scopus, Web of Science, COCHRANE, LILACS, DOSS, and gray literature were searched using the following terms (MeSH) or their combinations: molar, third; anti-inflammatory agents, non-steroidal; analgesia; preoperative period; pain management. RESULTS: From a total of 2903 articles, 31 (n = 2184 subjects) were selected. All studies presented a low risk of bias but exhibited high heterogeneity in methodology. Ten studies were selected for the meta-analysis. Preemptive analgesia for removal of third molars reduced average pain scores, especially those 1 h and 6 h after surgery (n = 151, p < 0.001, 95% CI = -2.81 to -0.97), reduced the average consumption of medication, and decreased the number of patients requiring medication without affecting the average time for its first consumption. CONCLUSION: In summary, most NSAIDs showed good results for inflammatory events and reduced average pain scores and consumption of rescue medication. However, more homogeneous and well-delineated clinical studies are necessary to determine a possible association between NSAIDs and the relief of inflammatory events.
Authors: Edson Luiz Cetira Filho; Paulo Goberlânio Barros Silva; Deysi Viviana Tenazoa Wong; Celia Choquenaira-Quispe; Francisco Rafael Alves Santana Cesário; Gisele de Sousa Nogueira; Alan Vieira Costa de Sousa; Andréa Silvia Walter de Aguiar; Said Goncalves da Cruz Fonseca; Fabio Wildson Gurgel Costa Journal: Clin Oral Investig Date: 2022-08-11 Impact factor: 3.606